Long-term effects of immunosuppressive therapy on lung function in scleroderma patientsCyclophosphamide pulse therapyFollow-upImmunosuppressantsInterstitisal lung diseaseLung functionSystemic sclerosisThe study aims to analyze the effects of induction treatment with cyclophosphamide (CYC) pulse therapy followed ...
Long-term administration of cyclosporin carries a risk of renal toxicity, and immunosuppressants are associated with an increased rate of malignant disorders. We undertook an open randomised study of the risks and benefits of two long-term maintenance regimens of cyclosporin in kidney-allograft recipien...
CONCLUSION: Apoptosis and caspase-3 are not only involved in the long-term renal I/R injury, but also mediate the divergent effects of immunosuppression in this model. 展开 关键词: apoptosis caspase-3 immunosuppressants ischemia/reperfusion injury ...
Moreover, while randomized controlled trials (RCTs) are gold standards for evaluating short-term safety, their typical duration is insufficient for observing long-term effects. For example, an RCT study provided evidence that patients receiving placebo had a higher incidence of severe pulmonary or ...
Fewer Side Effects: Unlike steroids, Cytopoint doesn’t causeweight gain,excessive thirst, orincreased appetite. This makes it more suitable for long-term use without the risk of secondary conditions likediabetesorCushing’s disease. No Behavioral Changes: Steroids often causerestlessnessoraggressionin...
Unfortunately, the addition of third immunosuppressants (e.g., mycophenolate mofetil, sirolimus), androgens, or growth factors to the standard h-ATG/CsA treatment did not improve outcomes [19]. Similarly, using more potent lymphocytotoxic agents such as alemtuzumab, rabbit ATG (r-ATG), or ...
The association of fetal exposure to valproate with serious long-term neurodevelopmental outcomes has highlighted the importance of capturing and evaluating long-term data. In this review we examine available evidence around the long-term effects of treatments used for the most common long-term ...
aYour Strategy is that although CNIs offer excellent short-term outcomes (approximately 1 year posttransplant), these immunosuppressants may contribute to nephrotoxicity and other long-term complications. 您的战略是,虽然CNIs提议优秀短期结果 (大约1年posttransplant),这些抑制免疫力之药剂也许对中毒性肾损害...
Introduction: Surgical complications may have not only immediate, but also long term effects on postoperative outcomes. Here, we aimed to investigate the impact of surgical complications requiring an early reoperation on patients' and gr... J Andrassy,S Wolf,M Rentsch,... - 《Transplant Internat...
In long-term survivors, quality of life was assessed using the 36-Item Short Form 36 Health Survey Questionnaire.RESULTSOne patient who had multiorgan failure before OLT died within 24 hr of surgery and two patients died within 1 year because of immunosuppressant-related complications. There have...