Pioglitazone provides greater long-term glycaemic control than glibenclamide [glyburide] in patients with type 2 diabetes mellitus (T2DM)
Common (1% to 10%): Hypoglycemia (5% or more when combined with glyburide) Uncommon (0.1% to 1%): Hypoglycemia Very rare (less than 0.01%): Lactic acidosis, vitamin B12 deficiency[Ref]In metformin-treated patients, the incidence of lactic acidosis has been about 1.5 cases per 10,000 patie...
Regarding the effects of metformin on CRC-related survival, a number of observational studies have investigated the association between metformin use and CRC-specific survival and overall survival. Metformin users with type 2 DM and CRC had a 30% improvement in overall survival compared with that of...
In a study in patients with NYHA class II or III heart failure the percentage of patients experiencing CHF progression during the study was 13.4% and 8.2% in patients receiving pioglitazone (n=262) and glyburide (n=256), respectively.
Compared to control, treatment with GW had no effect on mRNA expression of PPARγ, inflammatory cytokines, stretch response proteins, or transcription factors that may induce hypertrophy Conclusions Long-term PPARγ activation with GW did not prevent progressive LV remodeling in dogs with advanced ...
Background and Purpose We aimed to determine whether subjects aged 70 years who were treated with intravenous glyburide (RP-1127; BIIB093; glibenclamide) would have better long-term outcomes than those who received placebo.Sheth, Kevin N.Petersen, Nils H.Cheung, KenElm, Jordan J.Hinson, Holly...
Department of Internal MedicinePhDDepartment of Internal MedicineClinical Pharmacology & TherapeuticsCasner PR. Insulin-glyburide combination therapy for non- insulin-dependent diabetes mellitus: A long-term double-blind, placebo-controlled trial. Clin Pharmacol Ther. 1988;44(5):594-603. doi: 10.1038/...
In further experiments, intracellular recordings showed that 2-DG applications consistently hyperpolarize CA1 neurons, probably owing to adenosine-mediated activation of K + conductance (which could be prevented by DPCPX or 8-SPT, but not by a K ATP antagonist, glyburide). The 2-DG-LTP of ...
Preconditioning with cromokalim improves long-term myocardial preservation for heart transplantation. Ann Thorac Surg. 1998;66:417- 424.Kirsch M,Baufreton C,Fernandez C,et al.Preconditioning with cromakalim improves long-term myocardial preservation for heart transplantation. The Annals of Thoracic ...