Radiotherapy causes direct and long-term uterine damage. Ovariectomised and hormonally supplemented mice experience uterine artery endothelial dysfunction and pregnancy loss following transfer of healthy blastocysts. WHAT IS KNOWN ALREADY. The detrimental off-target impacts of cancer therapies on the ovary...
The long-term effects of radiotherapy and chemotherapy are becoming increasingly reconginzed as the cure rates of certain childhood malignancies improve. The endocrine system is particularly sensitive to cancer therapies. Long-term survivors of childhood cancer who received cranial irradiation have been ...
Therapy-related AML (t-AML) is a myeloid neoplasm that evolves secondary to cytotoxic therapy (chemotherapy and/or radiotherapy) for malignant or non-malignant diseases due to DNA damage in hematopoietic progenitor cells. Approximately 5–15% of adult AML patients are reported to have t-AML [1,...
Second malignancies in prostate carcinoma patients after radiotherapy compared with surgery Cancer, 88 (2000), pp. 398-406 View in ScopusGoogle Scholar 17 D.C. Hodgson, E.S. Gilbert, G.M. Dores, et al. Long-term solid cancer risk among 5-year survivors of Hodgkin's lymphoma J Clin Onco...
As presented above, glioblastomas could be cured when treated in the subcutaneous setting with radiotherapy, with long term anti-tumor immunity. On the other hand, intracranial tumors could not be cured, even though the dose was increased. In order to define the different tumor properties in the...
Erlandsson J, Fuentes S, Radu C, et al. Radiotherapy regimens for rectal cancer: long-term outcomes and health-related quality of life in the Stockholm III trial. BJS Open. 2021;5(6):zrab137. doi:10.1093/bjsopen/zrab137PubMedGoogle ScholarCrossref ...
There's been debate for decades on whether the long-term risk associated with nodal irradiation, particularly collateral heart and lung damage from internal mammary irradiation, outweigh the benefits of better disease control, notedJulia White, MD, a radiation oncologist at the Ohio State University ...
The long-term changes during late delayed radiation-induced brain damage were investigated by serial magnetic resonance (MR) imaging of eight patients over a mean follow-up period of 45 months after irradiation. The radiation damage appeared as an enhanced lesion on T-weighted MR images with gadol...
radiation-induced lung damageand Purpose: Recent improvements in lung cancer survival have spurred an interest in understanding and minimizing long term radiation-induced lung damage (RILD). However, there is still no objective criteria to quantify RILD leading to variable reporting across centres and ...
(lincRNAs,Ulitsky & Bartel, 2013), and from noncoding strands of protein-coding genes (naturally occurring antisense transcripts, NAT,Cabili et al., 2011; Rinn & Chang, 2012) (seeFig. 4). We will use the term long noncoding RNAs, abbreviated lncRNA to refer to the set of all no...