Nonetheless, optimizing health-related outcomes and minimizing suffering requires that severe TBI patients receive the appropriate type and level of care throughout the duration of their lives. Keywords Traumatic brain injury; Neurological consequences; Physical; Glascow coma score; Stress ulcersCraig H LichtblauScott RaffaKaveh AssadiChristopher WarburtonInternational journal...
This review will discuss the long-term consequences of TBI on the skeletal system and TBI-induced signaling pathways that contribute to the formation of ectopic bone, altered fracture healing, and reduced bone mass. 展开 关键词: osteoporosis growth hormone bone formation bone resorption heterotopic ...
Importantly, no significant differences in any outcome measure between nonperitraumatic mTBI and no TBI groups were observed. Conclusions and Relevance This cohort study found that mTBI was only associated with long-term consequences when it co-occurred with a traumatic event exposure. ...
but much remains unknown about the short-term and long-term consequences of these events, including potential cognitive impairment and risk of later-life dementia. This Expert Consensus Document is the result of a 1-day meeting convened by Safe Kids ...
long-term cognitive outcomes remain poorly understood. As the physical, cognitive and emotional consequences of concussion gain wider public attention, our incomplete knowledge of how to prevent, diagnose and treat such injuries endangers the health of our children in general and the health of their ...
Older adults with lower education are at greater risk for dementia. It is unclear which brain changes lead to these outcomes. Longitudinal imaging-based measures of brain structure and function were examined in adult individuals (baseline age, 45–86 yea
The intensive metabolic, cellular and vascular demands of the developing brain and low antioxidant reserves render the young brain more sensitive to reduced blood flow (Obermeier et al., 2013; Toga et al., 2006). The long-term consequences of an early age TBI include cognitive impairments and ...
The initiation, anatomic pattern, and extent of tau spread in traumatic brain injury (TBI), and the mechanism by which TBI leads to long-term tau pathology, remain controversial. Some studies suggest that moderate to severe TBI is sufficient to promote t
The complex interplay between HMGB1 and critical regulatory proteins (HIF1α, PARP, and γH2AX) underscores the potential genomic consequences of nuclear HMGB1 loss following TBI. The translocation of HMGB1 from the nucleus not only represents a loss of its DNA-protective functions but may also imp...
1 provides a general schema of the study. Throughout this paper, the term ‘significantly associated’ refers to statistical significance, as determined by a Bonferroni-corrected P-value threshold of P < 0.01, unless otherwise specified. Table 1 Demographic characteristics of participants Full ...