(优质)专业解读-药物与 QT 间期延长Long QT syndrome.docx,药物与导致 QT 间期延长 目录 TOC \o 1-3 \h \z \u 药物与导致 QT 间期延长 1 (一)抗心律失常药物 2 (二)促胃动力药物 4 (三)抗菌药物 4 (四)精神类药物 5 (五)麻醉相关药品 5 (六)添加剂 6 (七)其
Triple mutationKCNH2 geneKCNQ1 geneSCN5A genePolymorphic ventricular tachycardiaCongenital long QT syndrome (LQTS) is a rare hereditary disease, with an incidence of 1 in 2000, characterized by prolonged ventricular repolarization and malignant ventricular tachyarrhythmias. We report the case of a 30-...
The congenital long QT syndrome (LQTS) and short QT syndrome (SQTS) are genetic disorders caused by mutations in specific myocardial ion channels leading to abnormal ventricular repolarization. Clinical manifestations include a tendency to develop syncope or cardiac arrest due to spontaneous polymorphic ...
Long-QT syndrome (LQT, LQTS, Romano-Ward syndrome, subgroups: Jervell & Lange-Nielsen syndrome, Andersen-Tawil syndrome, Timothy syndrome, Ankyrin-B syndrome, Cardiac-only Timothy syndrome, Triadin knockout syndrome). Comment: It may be appropriate to limit the use of numbered LQTS to LQTS 1...
Molecular genetic testing identified three mutations in heterozygosity in the KCNH2, KCNQ1 and SCN5A genes, which is a rare finding and is associated with worse prognosis. 展开 关键词: Long QT syndrome Triple mutation KCNH2 gene KCNQ1 gene SCN5A gene Polymorphic ventricular tachycardia DOI: ...
Long QT syndrome is a rare disorder that can lead to dangerous heart rhythms, fainting and sudden cardiac arrest.
It is becoming clear that mutations in the KVLQT1, human "ether-a-go-go" related gene, cardiac voltage-dependent sodium channel gene, minK and MiRP1 genes, respectively, are responsible for the LQT1, LQT2, LQT3, LQT5 and LQT6 variants of the Romano-Ward syndrome, characterized by auto...
Long QT syndrome is a fascinating disease that represents one of the more common genetic causes of sudden death (at least 1 in 5,000 carry an LQTS mutation).1-3 Most patients with LQTS suffer from the autosomal dominant type, although a very rare, more virulent form called Jervell and ...
The hereditary long QT syndrome (LQTS) is a genetic channelopathy with variable penetrance that is associated with increased propensity to syncope, polymorphous ventricular tachycardia (torsades de pointes), and sudden arrhythmic death. This inherited cardiac disorder constitutes an important cause of mali...
Long QT syndrome due to a novel mutation in SCN5A: treatment with ICD placement at 1 month and left cardiac sympathetic denervation at 3 months of age. J Interv Card Electrophysiol 2009;26:41-5.Silver ES, Liberman L, Chung WK, Spotnitz HM, Chen JM, Ackerman MJ, Moir C, Hordof AJ, ...