Long QT syndrome caused by noncardiac drugs. Prog Cardiovasc Dis. 2003;45:415-27.Viskin, S., Justo, D., Halkin, A., & Zeltser, D. (2003). Long QT syndrome caused by noncardiac drugs. Progress in cardiovascular diseases, 45(5), 415-427....
The drug-induced long QT syndrome is a distinct clinical entity that has evolved from an electrophysiologic curiosity to a centerpiece in drug regulation and development. This evolution reflects an increasing recognition that a rare adverse drug effect can profoundly upset the balance between benefit ...
Drug-induced long QT syndrome in women: Review of current evidence and remaining gaps (rapid component of the delayed rectifier potassium current) blockers, via modulation of intra- and extracellular concentrations, may be of major importanc... Raymond Hreiche PharmD, PhD,Pierre Morissette PhD,...
Long QT syndrome is an uncommon inherited condition— meaning it's caused by genes passed on to you from your parents. The electrical activity of heart cells is controlled by a set of channels that pump minerals, such as sodium and potassium, in and out of cells. If you inherit genes ...
Introduction: QT dispersion (QTd) can be measured from three leads of the ECG in patients with myocardial ischemia. However, whether QT and JT dispersion (QTd, JTd) can be calculated from a three-lead of the ECG in drug-induced long QT syndrome (LQTS) in animals remains elusive. Therefore...
作者:Yap, Yee Guan; Camm, A. John; 出版年:2002-9 页数:120 定价:347.00元 ISBN:9780879934682 豆瓣评分 目前无人评价 评价: 内容简介· ··· To most cardiologists, the long QT syndrome is a relatively rare congenital and familial syndrome that affects children or young adults. However, in a...
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Many drugs result in QT/QTc interval prolongation (6). An abbreviated list of such drugs is presented in Table 1. In the majority of cases, drug-induced QT/QTc prolongation appears to result from blockade of the IKr ion channel responsible for the rapid component of the delayed rectifier ...
Our present study indicates that rabbit Purkinje fibers can be used as long QT2 (dofetilide-mimicking) and LQT3 (anthopleurin-mimicking) syndrome models, and confirms that drug-induced long QT1 (indapamide-mimicking) is absent. Our present study also shows the relationship between a ...
A risk assessment of drug-induced Long QT Syndrome (LQTS) associated with COVID-19 repurposed drugs was performed and compared to 23 well-known torsadogenic and 10 low torsadogenic risk compounds. Computer calculations were performed using pharmacokinetic and pharmacodynamic data, including affinity...