Long QT SyndromeCytochrome P-450 Enzyme SystemIon ChannelsElectrocardiographyRisk FactorsAction PotentialsMutationPolymorphism, GeneticThe drug-induced long QT syndrome is a distinct clinical entity that has evolved from an electrophysiologic curiosity to a centerpiece in drug regulation and development. This...
Long QT syndrome (LQTS) is a cardiovascular disorder characterized by an abnormality in cardiac repolarization leading to a prolonged QT interval and T-wave irregularities on the surface electrocardiogram. It is commonly associated with syncope, seizures, susceptibility to torsades de pointes, and risk...
Long QT syndrome is an uncommon inherited condition— meaning it's caused by genes passed on to you from your parents. The electrical activity of heart cells is controlled by a set of channels that pump minerals, such as sodium and potassium, in and out of cells. If you inherit genes ...
A risk assessment of drug-induced Long QT Syndrome (LQTS) associated with COVID-19 repurposed drugs was performed and compared to 23 well-known torsadogenic and 10 low torsadogenic risk compounds. Computer calculations were performed using pharmacokinetic and pharmacodynamic data, including affinity...
To most cardiologists, the long QT syndrome is a relatively rare congenital and familial syndrome that affects children or young adults. However, in addition to congenital LQTS there is a series of acquired forms of the syndrome, usually resulting from exposure to drugs that extend the duration ...
The methadone dose, was contain 15 demographic, biological, and pharmacological variables were taught as factors for QT prolongation. Methadone dose is presence in the cytochrome P-450 inhibitors, potassium level and liver function contribute to QT prolongation. Long QT syndrome can come with low ...
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Drug-induced long-QT syndrome and torsade de pointes: an underrated problem? Drugs that cause an acquired disorder of myocardial repolarization with a characteristic prolongation of the QT interval on electrocardiogram (ECG) are num... P Rao,PR Kowey - Europace : European pacing, arrhythmias, and...
Congenital long QT syndrome (LQTS) is a hereditary cardiac disease characterized by a prolongation of the QT interval at basal ECG and by a high risk of life-threatening arrhythmias. Disease prevalence is estimated at close to 1 in 2,500 live births. The
Long QT syndrome (LQTS) is an inherited dysrhythmia characterized by abnormally prolonged QT interval that can result in ventricular tachycardia (VT), ventricular fibrillation (VF) and sudden death. From: Post-Genomic Cardiology (Second Edition), 2014 ...