HSC self-renewal and lineage commitment depend on complex interactions with the microenvironment [27], and thus, the different results may be related to many other factors including their drug use profiles and patients’ conditions. For example, in renal transplant patients, a combination of ...
Further cultivation was accompanied with selection of cells with breaks near centromeres and homogeneously staining regions on chromosomes. Nonspecific destabilization of the karyotype (at the initial stages of selection) was accompanied with increased gene expression of hsc70 (constitutive iso-form of ...
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(2015), Long-term care use among old people in their last 2 years of life: variations across Finland. Health & Social Care in the Community. doi: 10.1111/hsc.12224 Author Information Gerontology Research Center, School of Health Sciences, University of Tampere, Tampere, Finland * Correspondence...
The working definition of an HSC is a cell that can provide long-term multilineage hematopoietic reconstitution when transplanted into an adult animal and can self-renew. HSCs in the adult animal reside in the bone marrow. However, studies in the mouse embryo have shown that the first HSCs ...
Existing studies have indicated that collaborative patents is a significant form of collaborative innovation, which has a long tradition and has advantages when used to evaluate collaborative innovation37. Patents with joint ownership can accelerate the innovation process37, which further indicates the ...
the main tissues in the skeletal system, which are connected to muscle, tendon, and ligament to form an entire system that protects the inside organs, allows body movement, secretes hormones to regulate the whole body’s metabolism, and stores hematopoietic stem cells (HSC) in the bone marrow...
affecting in this way transcription of HOX genes to promote cancer metastasis and progression. Interestingly, HOTAIR covers also a role for disturbed interaction of lncRNAs with other RNA species, mostly miRNAs for which it acts as a sponge in form of ceRNA. Specifically, HOTAIR was reported to...
A low-resolution structure of a similar, truncated form of the complete tetrameric enzyme, with dimerized reaction domains (RDs), was obtained using cryo-electron microscopy (cryo-EM). The dynamic nature of the RDs, as suggested by cryo-EM two-dimensional (2D) class averages, is observed ...
Collagen is the main constituent of a fibrotic scar, and TGF-β promotes its expression in HSC myofibroblasts.27,28,29Negishiet al.30recently performed a small-interfering (si)RNA screen of human lncRNAs to identify the molecules that contribute to cell proliferation. Alu-mediated p21 transcription...