Characterization of protein, long noncoding RNA and microRNA signatures in extracellular vesicles derived from resting and degranulated mast cellsMast cellsEVsproteomicslncRNAsmiRNAsMast cells (MCs) are known to participate in a variety of patho-physiological processes depending largely on the intragranular...
Furthermore, we identified pathways which were related to the medial thickness and formation of elastic fibers in yak lungs. These findings provide new insights into the high-altitude adaptation of yak and have important implications for understanding the physiological and pathological responses of large...
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Furthermore, TP is a pure prodrug and possesses no inherent binding to G-protein coupled receptors including prostanoid receptors. Pharmacokinetic studies in rats and dogs demonstrated that TPIS maintained relatively high concentrations of TP in the lungs yet had a low maximum plasma concentrations ...
In the context of atherosclerosis, miR-92a is also found in extracellular vesicles of coronary artery patients. Via this pathway, ECs receive the miRNA and increase proliferation, migration and therefore angiogenesis via THBS1. THBS1 is an adhesive glycoprotein that has been shown to bind ...
(which bind specifically to mannosyl- and glucosyl-containing extracellular glycoproteins on the cell membrane) for purification in the following steps. step1 antibody binding; step 2 pa-m.ecogii binding; step 3 methylation activation; step 4 ont sequencing. firstly, recombinant protein pa-m.ecog...
Their level of expression is generally lower than that of protein-coding genes and is more tissue-specific [55,58,59]. Biogenesis of lncRNAs is based on their location in respect to protein-coding genes, and lncRNAs can thus be classified into four categories: (1) long intergenic non-coding...
Although for many years the function of lncRNAs remained largely unknown, with many considering them as ‘genetic debri’, we now know that these RNA molecules can play a catalytic role in regulating protein-coding gene expression at epigenetic, transcriptional, post-transcriptional, translational and...
Among them, FSCN1 is expressed in mesenchymal tissues and the nervous system, FSCN2 is expressed in the retinal photoreceptors, and FSCN3 is a testis-specific protein [3]. FSCN1 is located at the membrane ruffles, micro spikes, and stress fibers and induces membrane protuberance. The main ...
Electrospinning pursues a biomimetic approach in the scaffold design [48,49] by generating nano- and microfibers mimicking the native extracellular matrix (ECM) morphology and these fibers can be easily functionalized with active biomolecules (i.e. drugs, growth factors, proteins, etc.). Recently,...