Some bones of the body are constituted by cartilaginous supports in which growth is produced both with the ossification process that extends from the center of the bone towards its borders in a process so called endochondral ossification. In this period of bone tissue morphogenesis the factors contr...
It increased interradicular bone volume and mandibular condyle trabeculae volume, increasing the percentage of cartilage and osteoclast number. CONCLUSION: These findings indicate that administration of ALN to growing animals alters the endochondral ossification process, and thus alters growth....
cells as early as E11.5 could serve as the source of osteoblasts in the bone marrow cavity and Col2+ cells labeled at E13.5 continuously generated descendants which could be traced in the growth cartilage, the perichondrium at P0 and the secondary ossification center in the epiphyseal at P21...
Endochondral ossification, a conversion process from nonvascularized and hypoxic cartilage to highly vascularized bone, plays a crucial role in osteoarthri... T Saito,H Kawaguchi - 《Osteoarthritis Cartilage》 被引量: 99发表: 2010年 HIF-2α inhibition disrupts leukemia stem cell metabolism and impair...
During further ossification of the long bone cortices, the number of necrotic cells increased markedly. In addition to necrotic cells, healthy osteoblasts, osteocytes and perichondral tissue were present, indicating that an artifact can be excluded. The importance of cell necroses in the process of...
Prevention of heterotopic bone formation after total hip arthroplasty: a prospective randomised study comparing postoperative radiation therapy with indome... Heterotopic ossification (HO) after total hip arthroplasty is known to be a major complication with an impact on the functional outcome. Efforts ...
A long bone forms by a process known as ___ ossification. The process of bones increasing in thickness is known as what? a. Closing of the epiphyseal plate b. Epiphyseal plate closure c. Appositional growth d. Concentric growth A long bone's growth in diameter is accomplished by which...
Objective To observe the early postnatal long bone development in Fgfr2+/S252W mutant mice and littermate wild-type (WT) mice, and explore the effect of continued function enhancement of fibroblast growth factor receptor 2 (FGFR2) gene on endochondral ossification. Methods A mouse model of Fgfr...
The role of Dickkopf-1 in bone development, homeostasis, and disease 2009, Blood Show abstract Endochondral ossification: How cartilage is converted into bone in the developing skeleton 2008, International Journal of Biochemistry and Cell Biology Show abstract A pathway to bone: Signaling molecules an...
The truncated limbs observed in p63 null mice suggest that P63 may contribute to long bone development by playing a role during endochondral bone formation. However, how P63 regulates target gene expression and is linked to endochondral ossification remains largely unknown. Here we present some ...