Long-acting opioids (LAO) are associated with an approximately 5-times higher incidence of low testosterone levels compared with short-acting opioids (SAO) in men with chronic pain, according to a study published in the Clinical Journal of Pain. [ 1 ] This retrospective study included 81men (...
However, in general, the patients who previously had overused short-acting opioids were more likely to overuse the long-acting ones. Twenty-four patients (8 percent) qualified for 'prescription opiate abuse,' necessitating discontinuation of the medication. Patients more likely to abuse the ...
Prescription opioid analgesics, particularly short-acting opioids, are misused and abused by excessive ingestion of intact tab-lets, and by intranasal and ... S Daniels,F Clark,R Spivey,... - 《Journal of Pain》 被引量: 6发表: 2009年 加载更多来源...
Long- or short-acting opioids for chronic non-malignant pain? A qualitative systematic review. Acta Anaesthesiol Scand. 2014;58:390–401. Article CAS PubMed Google Scholar Chou R, Turner JA, Devine EB, Hansen RN, Sullivan SD, Blazina I, et al. The effectiveness and risks of long-term ...
9,19,32 Of particular concern is our finding that a high proportion (81.8%) of adults who use both drugs concurrently for a long term are prescribed stimulants and short-acting opioids. Short-acting opioids are recommended for acute pain, but their long-term use has been discouraged by ...
produced a dose-dependent slow-onset (20–60 min) long-acting (at least 6–12 h) increase in NAc DA, whereas cocaine (10 mg/kg, i.p.) produced a robust rapid-onset short-duration increase in NAc DA. (b) The effect of 31,345 (10 and 20 mg/kg, i.p.) pretreatment on cocaine...
Codeine remained the most commonly used opioid at 1 year after surgery (87.5%), but long-term opioid users also used more potent long-acting opioids, including transdermal fentanyl (1.6%) and oxycodone (15.9%). Among the early users group, those who received a prescription within 60 days of...
ZOL is a short-acting hypnotic, with in vivo occupancy of the GABAA receptor BZ sites lasting only about 15–30 min after i.p. injection of 10 mg/kg in mice (Benavides et al, 1988). As discussed above with regard to FLU antagonism, the BZ effect may need to last longer than 15 ...
5 Consequently, although most patients are prescribed IR opioids for short-term treatment (<14 days),5 given the large number of patients prescribed IR opioids, the number treated long-term could approach or even exceed the number treated long-term with ER opioids. Additionally, acetaminophen is...
The latter is also referred to as long-acting injectable antiretrovi- ral therapy or LAI ART for short. Lessons learned from the longer-standing use of LAIs in the fields of mental health and addiction treatment hold particular relevance given that they treat a population that includes people ...