Yamaguchi Y, Hanaki H, Yanagisawa C, Ikeda-Dantsuji Y, Hashimoto T, Yazaki H, et al. Characterization of beta-lactam antibiotic-induced vancomycin-re- sistant MRSA (BIVR) in a patient with septicemia during long-term vancomy- cin administration. J Infect Chemother 2009;15:274-8....
It was reported that some methicillin-resistant Staphylococcus aureus (MRSA) show resistance to vancomycin (VCM) and 尾-lactam antibiotics; thus, they are termed 尾-lactam antibiotic-induced VCM-resistant MRSA (BIVR). The VCM resistance of MRSA is induced by the administration of 尾-lactam ...
Yamaguchi Y, Hanaki H, Yanagisawa C, Ikeda-Dantsuji Y, Hashimoto T, Yazaki H, et al. Characterization of beta-lactam antibiotic-induced vancomycin-re- sistant MRSA (BIVR) in a patient with septicemia during long-term vancomy- cin administration. J Infect Chemother 2009;15:274-8....
From a theoretical PK and PK/PD perspective, our data support a potential longer antibiotic activity than previously considered both for single or double 1500 mg dose administration and for a possible mis-dosing of this molecule in different settings. The evidence of treatment failures with the ...