“Basal” indicates a long-acting insulin given once or twice daily that will act continuously in the background, whereas “bolus” indicates a rapid-acting insulin that is given at mealtimes and possibly snacks to cover the glucose rise from CHO ingestion. ...
The approval process for LAIs requires some degree of correlation using bioequivalence and bioavailability (BABE) to establish their therapeutic effectiveness. The guidelines for Oral Generic Products are well-defined in comparison to polymeric long-acting drug products [145,147]. This may be due to ...
In Silico Examination of Initiation of Long-Acting Insulin Analogs Toujeo Compared to Lantus Under 3 Dosing Titration Rules in Virtual Type 2 Diabetes Subjects.doi:10.1177/1932296819861586Jochen SieberMark WeinheimerGail KongableSusan RiddleYung-Yeh Chang...
A parenteral long-acting sustained drug delivery system, providing continuous and controlled release of drugs, reduces administration frequency and GI side effects, while improving PK and patient compliance [1], [11]. Parenteral dosing via hypodermic injections, however, is invasive, painful, requires...
Metabolic syndrome, which increases the risk of obesity and type 2 diabetes has emerged as a significant issue worldwide. Recent studies have highlighted the relationship between metabolic imbalance and neurological pathologies such as memory loss. Gluca
This implanted unit doses pharmaceutical fluids into the human- or animal body. The new design includes a known, edge-controlled, valveless axial piston pump (2). The piston (3) is driven (6) under control, in rotation and axial translation. A fluid reservoir (5) is connected to the suc...
24.Cohen, P, Rogol, AD, Howard, CP, Bright, GM, Kappelgaard, AM, Rosenfeld, RG, et al.. Insulin growth factor-based dosing of growth hormone therapy in children: a randomized, controlled study.J Clin Endocrinol Metab2007;92:2480–6.https://doi.org/10.1210/jc.2007-0204.Search in Goog...
These agents include gluca- gon-like peptide-1 (GLP-1) and glucose-depen- dent insulin releasing polypeptide (GIP), among which GLP-1 plays a more important role. There Long-acting anti-diabetic agent Figure 1. Construction of Exendin-4-IgG4 fusion protein. A. Schematic diagram of the ...
2 Long-acting insulin analogs mimic the action of human insulin but have greater duration of action, lower peaks of action, and lower risks of hypoglycemia.2, 3, 4 The global burden of diabetes was 673 billion US dollars (USDs) in 2015.5 In Canada, long-acting insulins and analogs were...
These medications are available as oral and, for many, also as long-acting injectable (LAI) formulations. LAI antipsychotic medications are formulated to facilitate the sustained release of the deposited antipsychotic over a number of weeks, thus increasing the dosing interval required for the ...