Adj.1.long-acting- active over a long period of time long- primarily temporal sense; being or indicating a relatively great or greater than average duration or passage of time or a duration as specified; "a long life"; "a long boring speech"; "a long time"; "a long friendship"; "a...
Long-acting insulins are used to provide a basal level of insulin. Ultralente insulin reaches a peak gradually (14–18h after injection), with a duration of action of up to 24h. Similar to lente insulin, ultralente is a suspension of large, zinc-containing crystals that have been precipita...
Studies on Long-acting Insulin: Crystal Structure of Arg-B31 Human Insulin at 2.0A Resolution. Sci China B. 36(12):1501-9Ren Bin,Wang Dacheng,Chang Wenrui et al.Studies on long-acting insulin:crystal structure of Arg-B31 Human insulin at 0.2nm resolution.Science in China. 1993Ren Bin,...
Insulin detemir is a novel long-acting insulin analogue with a unique mechanism causing prolonged duration of action. This is because of its self-association into hexamers and dihexamers and to bind reversibly to albumin. Insulin detemir remains soluble after it is injected. Clinical studies showed...
que action profile. LAPS Insulin115: A novel ultra-long-acting basal insulin with a unique action profile.LAPS Insulin115: A novel ultra-long-acting basal insulin with a unique action profile.antidiabetic drugbasal insulindrug mechanisminsulin analogues...
which can improve insulin sensitivity and lipid metabolism in addition to having anti-fibrotic effect. Thus, addressing both GLP-1 and FGF21 may be an effective therapeutic strategy for NASH due to their complementary mechanisms of action. YH25724 is a novel long-acting dual agonist, which is ...
The effects of long-acting somatostatin analogues, angiopeptin (AGP) and Sandostatin (SMS), on the early decline in the lens content of glutathione (GSH), ATP and NADPH and increase in sorbitol were studied in STZ diabetic rats, and comparison was made with the effect of insulin. Three fact...
Several long-acting rhGH products have been studied in GHD patients over the past 15 years. The first approved long-acting rhGH product, Nutropin Depot® (Genentech, Inc, South San Francisco, California, USA), is no longer marketed because of the difficulties with manufacturing of the product...
Insulin degludec is a new basal insulin that forms soluble multihexamer assemblies after subcutaneous injection, resulting in an ultra-long action profile. This study aimed to assess efficacy and safety of insulin degludec injected once a day or three times a week compared with insulin glargine once...
Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing Yan Weng, Tetsuya Ishino, Annette Sievers, Saswata Talukdar, Jeffrey R. Chabot, Amy Tam, Weili Duan, Kelvin Kerns, Eric Sousa, Tao...