Long-acting growth hormone. Peadiatr Drugs 2013;15(6):427e9.Charlotte Höybye , Jens Sandahl Christiansen . (2014) Growth hormone replacement in adults - Current standards and new perspectives. Best Practice & Research Clinical Endocrinology & Metabolism Online publication date: 1-Oct-2014. /...
The heiGHt Trial investigators report that once-weekly treatment with lonapegsomatropin offers noninferior and indeed superior annualised height velocity to that achieved with daily somatropin for children with growth hormone deficiency.
Opko Health and Pfizer announced positive top-line results this week for an investigational long-acting growth hormone injection, noting the therapy was safe and effective for prepubertal children with GH deficiency, according to a press release from t...
Adherence to daily subcutaneous growth hormone is challenging for patients. Thus, several companies have pursued the creation of long acting rhGH. These agents can be divided broadly into depot formulations, PEGylated formulations, prodrug formulations, non-covalent albumin binding GH and GH fusion ...
Background: Growth hormone (GH) replacement therapy in adults and children has found broad acceptance by endocrinologists and patients, but the need for daily injections remains a significant barrier to more widespread use. Long-acting Formulations: Several approaches have been taken to develop long-...
OBJECTIVE: We assessed the efficacy and safety of a weekly pegylated human growth hormone (PEG-rhGH) (Jintrolong) vs daily rhGH for children with growth hormone deficiency (GHD). DESIGN: Phase II and III, multicenter, open-label, randomized controlled trials. METHODS: 108 and 343 children with...
Long-acting human growth hormone (HGH) backbone|长效人生长激素(HGH)主链 基本信息 更多信息 中文名称: 长效人生长激素(HGH)主链 中文同义词: 长效人生长激素(HGH)主链 英文名称: Long-acting human growth hormone (HGH) backbone 英文同义词: Long-acting human growth hormone (HGH) backbone CAS号: 分子...
SHANGHAI, Oct. 26, 2019 /PRNewswire/ -- VISEN Pharmaceuticals announces China Phase 3 clinical study initiation for TransCon human growth hormone, the first unmodified long-acting growth hormone in China
Several evidence gaps exist regarding the use of long-acting polyethylene glycol recombinant human growth hormone (PEG-rhGH) in children with idiopathic short stature (ISS), particularly studies conducted in real-world settings, with long-term follow-up, involving varied dosing regimens, and in compa...
Use of a growth hormone protein and polynucleotides encoding same comprising an amino-terminal carboxy-terminal peptide (CTP) of chorionic gonadotrophin and two carboxy-terminal cho