Locus is a set of points that satisfies a given figure situation or condition. Learn its meaning, definition, locus of points, theorems with examples for different shapes at BYJU'S.
The influx of phylogenomics and population genomics into the mainstream makes it important to understand and incorporate the biology of genome structure into our thinking about evolutionary analysis with molecular data. Some well-known population genetic phenomena can help make this connection. The genetic...
Collectively, these results illustrate the power of our approach to reveal new insights into disease biology by identifying the pathogenic cell type of disease alleles. Download: Download high-res image (2MB) Download: Download full-size image Figure 1. Cell Type Specificity of Intralocus Regulatory...
There were 57,714 cases and 110,358 controls of European ancestry under the clinical definition of MD, which were subsequently combined with the aforementioned non-European clinically ascertained studies by meta-analysis (100,089 cases and 214,415 controls in total) (Extended Data Fig. 4 and ...
3National Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan; 4Division of Pediatric Otolaryngology Head & Neck Surgery, Cincinnati Children's Hospital Research Foundation, Cincinnati, OH, USA; 5Department of Otolaryngology, College of Medicine, University of Cincinnati...
Simple sequence repeats (SSRs, also known as microsatellites) are repetitive sequence motifs of one to six base pairs (bps) scattered throughout all known genomes [1]. The extensive length differences that may be achieved by microsatellites and their high rate of polymorphism have facilitated their...
ADefinition of a QTL A quantitative trait is one that has measurable phenotypic variation within a population owing to underlying variability in genetic and/or environmental influences. A QTL is a genetic locus in which allelic variation affects variation in the observed phenotype (Grisel, 2000). ...
A more precise definition of the bcl-6 locus and of the frequency of its involvement in NHL requires cloning and characterization of additional bcl-6 sequences and studying additional tumor cases. Nevertheless, the finding that various translocation partner chromosomes have been joined to the same ...
The biology of the HLA system is less well understood. Class 1 factors are distributed in all tissues except erythrocytes. Class 2 factors are substantially restricted to β-lymphocytes and mononuclear phagocytic cells and the Class 3 complement factors are directly involved in the activation of the...
(Table1). The single bovine TRBV gene that lacked significant homology to any of the human TRBV genes displayed 76.6% identity with the murine TRBV1 gene (which lacks a human orthologue) and was placed in subgroup TRBVX. The subgroups thus established generally adhered to the definition of...