Protruding from the cell body are dendrites, which are short projections of the plasma membrane that receive information from other neurons or the environment. Dendrites have receptor sites, which are ligand-gated ion channels. These receptor sites detect chemical signals from other neurons as well ...
The GABA response was fast; reflecting the activation of GABA- gated ion channels (Figure 1A, left panel). Control oocytes without microtransplanted plasma membranes challenged with 3 mM GABA did not produce any cur- rent (Figure 1A, right panel). Thus, we demonstrated expression of functional...
The secondtransmembrane domain(TM2) ofS1Rincludes residues 91–107. • The S1R cytosolic region contains three α-helices. • The chaperone domain structure is largely unperturbed by the addition of TM2. Abstract The sigma-1 receptor (S1R) is a ligand-regulated membrane chaperone protein as...
However, the efficacy of CDX1401 was substantially improved by pretreatment of patients with CDX-301, a recombinant FMS-like tyrosine kinase-3 ligand (Flt3L) that increases DC numbers within peripheral blood, resulting in higher T-cell responses across all patients (clinicaltrials.gov: NCT02129075...