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The 50% inhibitory concentration (IC50) was calculated with a four-parameter logistic regression using GraphPad Prism (GraphPad Software Inc.). If the curve of individual mouse fails to produce positive fit (i.e. negative titer), suggestive of no neutralization activity, the value was converted ...
As for the Krt19 lineage-tracing model, the extent of DR was similar between the two groups (Figure S4K), most likely due to greater BEC-to-hepatocyte conversion in the VEGFA mRNA-LNP-treated group. The findings were further supported in the acute APAP/p21-induced liver injury (Figure 3H...