从差异表达的 lncRNA 中挑选了 5 个之前未见报道的 lncRNA 进行了 RT-PCR 验证,其中 CBR3-AS1 表达量最高(图 d),并且 CBR3-AS1 表达量与多种乳腺癌细胞的 ADR 抗性呈现正相关(图 e-g)。同时,TCGA 数据分析显示,CBR3-AS1 在乳腺癌组织中高表达(图 h),并且 CBR3-AS1 高表达伴随较差的临床预后(图 ...
从差异表达的 lncRNA 中挑选了 5 个之前未见报道的 lncRNA 进行了 RT-PCR 验证,其中 CBR3-AS1 表达量最高(图 d),并且 CBR3-AS1 表达量与多种乳腺癌细胞的 ADR 抗性呈现正相关(图 e-g)。同时,TCGA 数据分析显示,CBR3-AS1 在乳腺癌组织中高表达(图 h),并且 CBR3-AS1 高表达伴随较差的临床预后(图 ...
目的探讨长链非编码RNA CBR3-AS1(lncRNA CBR3-AS1)是否通过靶向调控miR-5195-3p的表达从而促进胃癌细胞增殖,迁移及侵袭.方法体外培养正常胃上皮细胞GES-1与胃癌细胞系HGC-27,NCI-N87,AGS,采用实时荧光定量聚合酶链反应(qRT-PCR)检测CBR3-AS1,miR-5195-3p的表达量;分别将si-NC,si-CBR3-AS1,si-CBR3-AS1...
BACE1-AS DLX6-AS1 LINC00162 PTCSC1 BCAR4 DNM3OS LINC00271 PVT1 BCYRN1 DSCAM-AS1 LSAMP-AS3 RMST BDNF-AS1 EPB41L4A-AS1 MALAT1 SCAANT1 BOK-AS1 ESRG MEG3 SNHG11 BPESC1 FMR4 MESTIT1 SNHG3 CASC2 GAS5 MIAT SNHG4 CBR3-AS1 GDNFOS MIR100HG SNHG5 CCAT1 H19 MIR155HG SOX2-OT CDK...
Overexpressed lncRNA PlncRNA-1 (transcript Variant 3 of CBR3-AS 1) promotes the proliferation and apoptosis of prostate cancer cells15. Androgen receptor (AR) promotes PlncRNA-1 expression. Furthermore, PlncRNA-1 mediates microRNA sponging, targeting AR, a process that protects AR from micro...
Long Non-Coding RNAs Expression in Breast Cancer: CBR3-AS1 LncRNA as a Sensitive Biomarker 2021, Asian Pacific Journal of Cancer Prevention View all citing articles on Scopus Hypoxia-mediated cancer stem cell resistance and targeted therapy
CBR3-AS1-1, CBR3-AS1-2, CCAT1, CCAT2, CCDC26, CCEPR, CRNDE, CTB-89H12.4, CTBP1-AS, DLEU1-1, DLEU1-2, DNM3OS-1, DNM3OS-2, DRAIC (LOC145837), DSCAM-AS1-1, DSCAM-AS1-2, EGFR-AS1, EGOT, ENS*** ENS*** ENS*** EPB41L4A-AS1, EPB41L4A-AS2, EWSAT1, FALEC, FAS-...
2021 年 1 月,中国医科大学药学院高华、魏敏杰教授和赵琳教授为共同通讯作者,在 Journal of Experimental & Clinical Cancer Research (IF: 11.161) 杂志发表了题为“LncRNA CBR3-AS1 regulates of breast cancer drug sensitivity as a competing endogenous RNA through the JNK1/MEK4-mediated MAPK signal pathway...
5p表达对鼻咽癌细胞的增殖与侵袭的抑制作用(P<0.05).小鼠移植瘤实验显示,下调lncRNA CBR3-AS1表达可上调miR-145-5p表达,从而下调FSCN1表达,抑制鼻咽癌移植瘤的生长(P<0.05).lncRNA CBR3-AS1在鼻咽癌组织中上调表达,下调lncRNA CBR3-AS1表达可通过调控miR-145-5p/FSCN1轴抑制鼻咽癌细胞的增殖与侵袭,促进细胞凋亡...
LncRNA CBR3-AS1miRNA-145-5pFN1OXIDATIVE STRESSRNAINFLAMMATIONOXYMATRINEGENEGrowing evidence suggested that long non-coding RNA (lncRNA) played a crucial role in the progression of ulcerative colitis (UC). Therefore, the purpose of this study is to understand how the lncRNA CBR3-AS1, which has...