该研究从LncRNA调控高糖诱导的血管平滑肌细胞衰老及成骨样转分化的角度,揭示了糖尿病性血管早衰和钙化新的调节机制,为延缓血管早衰提供了新思路。该篇在线发表的论文题为“LncRNA-ES3/ miR-34c-5p/ BMF axis is involved in regulating high-glucose-induced calcification/ senescence of VSMCs”,刘幼硕教授为通...
大多数lncRNA的外显子/内含子长度与mRNA编码基因的长度相似(Gerstein et al. 2007;Guttman et al. 2009)。然而,在植物中也有例外,如鹰嘴豆和亚洲棉,长基因间ncRNAs (lincRNAs)的平均外显子长度明显长于mRNA(Khemka et al. 2016;Zou et al. 2016)。3组织特异性LncRNA的组织特异性表达水平在哺乳动...
[[ceRNA]])用来分析基因间lncRNAs的功能,而不需要p.Xu等人(2016)用基因本体(GO)术语成功地注释了...
在本研究中研究者发现,由lncRNA LOC90024编码的小蛋白SRSP调节SRSF3对转录因子Sp4外显子3的识别和结合,导致Sp4外显子3的包含。在癌细胞中,SRSP上调,并增加Sp4外显子3上SRSF3的识别和结合,以诱导外显子3的包含,从而产生Sp4基因的“癌症”剪接变体L-Sp4;在正常细胞中,SRSP缺失或低水平表达,因此SRSF3弱识别并...
^16. Lafarga M, Berciano MT, Pena E, Mayo I, Castaño JG, Bohmann D, Rodrigues JP, Tavanez JP, Carmo-Fonseca M. Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. Mol Biol Cell. 2002 Aug;13(8):2771-82. ...
7926 Accesses 256 Citations Metrics details A Correction to this article was published on 16 June 2020 This article has been updatedAbstract Metastasis is a well-known poor prognostic factor in cancer. However, the mechanisms how long non-coding RNAs (lncRNAs) regulate metastasis in colorectal ca...
相近牌号:NS142(中国)、NC21FeDu (法国)、W.N r.2.4858 NiCr21Mo (德国) NA16 (英国) Incoloy825、UNS NO8825(美国)NiFe30Cr21Mo3(ISO)化学成分:镍Ni:38-46铬Cr:19.5-23.5铁Fe:余量碳C:≤0.025锰Mn:≤1.0硅Si:≤0.5钼Mo:2.5-3.5铜Cu:1.5-3.0钴Co:≤1.0...
Statistical analyses were performed by two-tailed unpaired Student’s t test (a, c, d). n.s., not significant. Source data are provided as a Source Data file. Full size image VAL abrogates the Vimentin–Trim16 interaction In light that Trim16, an E3 ligase, was previously reported as ...
8. 最大输入功率:1 mW(0 dBm)。9. 本振频率精度:在18°C时为1 kHz。10. 本振频率稳定性:±0.5 ppm。11. 电源电压:+9到+36 V DC。12. 电流消耗:在12V DC下典型为250 mA。13. 最大外壳温度:+55°C。14. 重量:230克。15. 尺寸:82 x 64 x 22毫米。16. 应用领域:包括通信、卫星...
l n c R N A与慢性肾病关系的研究进展* 苑佳奇沈晓丹虞飞张学明ә (包头医学院基础医学与法医学院,包头014040)摘要近年来,慢性肾病(c h r o n i c k i d n e y d i s e a s e,C K D)的发病率和死亡率逐年升高,越来越引起人们的重视㊂其发病机制复杂,病情往往持续性进展,最终发展为终...