Thus, prevent phosphorylation and promote growth and differentiation of the CRC cells. PVT1 act as oncogene that facilitates the expression of MYC is confirmed by chromosome engineering. Both MYC and PVT1 are expressed in equal amounts in the HCT116 cell lines. The reduction of PVT1 ...
Purpose: Endoplasmic reticulum (ER) stress has a significant effect on cancer cells. Increasing numbers of studies indicate that long non-coding RNAs (lncRNAs) promote the development of colon adenocarcinoma (COAD), but the relationship between ER stress-related lncRNAs and the pr...
A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability. Nat Commun. 2021;12:5572. Article CAS PubMed PubMed Central Google Scholar Nakayama Y, Fujiu K, Yuki R, Oishi Y, Morioka MS, Isagawa T, et al. A long non-coding RNA regulates ...
DNA:DNA:RNA triplexes that are formed through Hoogsteen base-pairing of the RNA in the major groove of the DNA duplex have been observed in vitro, but the extent to which these interactions occur in cells and how they impact cellular functions remains elusive. Using a combination of bioinforma...
It maybe more interesting to measure whether overexpression of TNRG14 could promote the injury or inflammation in normal animal. To act as the ceRNA of miRNA is a major regulatory mechanism for lncRNA [25]. Currently, miR-136–5p was found as a target miRNA of SNHG14. miR-136 exerted ...
The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis. Nat Commun. 2021;12(1):3734. Article CAS PubMed PubMed Central Google Scholar Zhai W, Zhu R, Ma J, Gong D, Zhang H, Zhang J, et al. A positive feed-forward loop between LncRNA-UR...
The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis. Nat Commun. 2021;12(1):3734. Article CAS PubMed PubMed Central Google Scholar Zhai W, Zhu R, Ma J, Gong D, Zhang H, Zhang J, et al. A positive feed-forward loop between LncRNA-UR...
(UST, uronyl 2-sulfotransferase), GO:0055114~oxidation-reduction process (CYP46A1), GO:0046856~phosphatidylinositol dephosphorylation (INPP5J), GO:0006094~gluconeogenesis (SLC25A1, solute carrier family 25 member 1), GO:0006629~lipid metabolic process (FABP6, fatty acid binding protein 6), GO:...
Esophageal squamous cell carcinoma (ESCC) is one of the most common types of cancer and the leading causes of cancer-related mortality worldwide, especially in Eastern Asia. Here, we downloaded the microarray data of lncRNA expression profiles of ESCC patients from Gene Expression Omnibus (GEO) ...
[63,64]. Effectors of pyroptosis are activated and transferred to the membrane to induce glial rupture, releasing more inflammatory mediators, which promote the progression of Parkinson’s disease with NLRP3[24]. Thus, the NLRP3 pathway may provide a new therapeutic avenue for Parkinson’s ...