To further elucidate the specific hepatic cell type implicated in COVID-19 pathophysiology, scRNA-seq analysis was conducted on five representative liver tissue types, including healthy, human foetal, cirrhotic, tumour, and precancerous, comprising over 300,000 single cells. In liver cirrhosis, a p...
The TCM treatment principles of NAFLD advocate phased approaches: initial treatment focuses on soothing the liver and qi, as well as fortifying the spleen and stomach, while intermediate and advanced stages emphasize enhancing the spleen and qi, resolving blood stasis, dissipating nodules, clearing hea...
To further elucidate the specific hepatic cell type implicated in COVID-19 pathophysiology, scRNA-seq analysis was conducted on five representative liver tissue types, including healthy, human foetal, cirrhotic, tumour, and precancerous, comprising over 300,000 single cells. In liver cirrhosis, a p...
The core TCM pair, Angelicae sinensis radix-Trionycis carapax, appeared pivotal in this context. The underlying mechanism might involve the modulation of key genes, such as MAPK3 and SRC, and the regulation of pathways, including the cancer pathway, TNF signaling pathway, a...
(TCM) in the prevention and treatment of NASH.Citation17In TCM theory, “spleen deficiency, phlegm, and stasis” is considered the underlying pathogenesis of NAFLD.Citation18Based on this theory, our research group developed the TCM formula Jiangzhi Granule (JZG) (alternatively named Salvia–Ne...
We studied the effects of C/EBPβ -Phospho-Thr217 signaling that is evolu- tionarily conserved (identical in human C/EBPβ -Phospho-Thr266) on macrophage inflammasome activity and liver injury induced by hepatotoxins in mice and humans. Results The modulation of Fas-L induced liver ...
Lu, W LChen, L YWang, S LYao, N LSun, T TYan, JWan, F