With jaundice, the skin and the whites of the eyes take on a yellowish color as a result of the accumulation of bilirubin and bile pigments in the blood. This is a sign that the liver or the biliary system is not functioning properly. Other symptoms of liver disease include an enlarged ...
Liver cell damagein liver failure depends on the type, duration, and severity of the toxic agent. The deterioration of liver functions, includingdetoxificationand metabolic and regulatory functions, leads to accumulation of various toxic substances such asbilirubin,bile acids, ammonia,protein breakdownpro...
converting stored sugar to usable sugar when the body’s sugar levels fall below normal, destroying old red blood cells, and producing bile to break down and digest fats.
in its activities that it is analogous to a factory for many chemical compounds, a warehouse with short- and long-term storage capabilities, a power plant producing heat, a waste disposal plant excreting waste, and to a chemistry lab regenerating tissue that has not been too severely damaged....
The liver responds to cell damage by producing strands of scar tissue that surround islands (nodules) of healing cells, making the liver knobby. At first, the inflammation in the liver causes it to swell. As the disease progresses and the amount of scar tissue in the liver increases, the ...
Gut epithelial barriers do not simply exclude luminal antigen; they enable a regulated uptake tailored to support different requirements of the tissue at different ages, and different anatomical sites. The liver limits dissemination of gut material via blood whereas gut-draining lymph nodes restrict lym...
153, 154 Owing to this possibility, though it may not be immediately apparent that hyperlipidemia could be an index of altered lipoproteins from the portal system in clinical sepsis, the role of this mechanism may be as important, if not more important than the other possibilities elaborated ...
This is because not only were the trials underpowered but were possibly not long enough to evaluate its effectiveness. Hence, stagliptin effect should be assessed in clinical trials of longer duration with larger number of enrolled patients with NAFLD/NASH. PTX PTX can be o...
The pathogenic role of B cells in autoimmune diseases has been established in diabetes type 1, SLE, and arthritis.6By presenting self-antigens, producing autoantibodies and secreting IL-21, B cells can contribute to the induction and maintenance of autoimmune diseases. Consequently, targeting B cel...
Producing bile, a fluid that aids digestion Fatty liver disease develops when an excess of fat builds up in and around the liver. It's fairly common in humans, and proper management can prevent it from progressing to more serious conditions or permanent liver damage. ...