After excluding individuals with missing registry linkage (n = 1457), baseline liver disease (ICD-10 codes K70-K77 or C22; n = 299), chronic viral hepatitis (n = 89), or missing anthropometric measurements (n = 338), the final study cohort comprised 40,922 individuals...
The International Classification of Diseases (ICD-10) recognizes several forms of alcoholic liver disease (ALD; see ICD-10, K70), sometimes considered stages [8], that range from relatively mild and reversible alcoholic hepatic steatosis (fatty liver) (K70.0) and alcoholic hepatitis (K70.1), to...
(International Classification of Diseases, 10th revision [ICD-10]: C22.0-22.8 and a proportion of C22.9) and its six etiologies (liver cancer due to hepatitis B, hepatitis C, alcohol use, other causes, NASH and hepatoblastoma) in China between 1990 and 2021 were extracted from the Global ...
The most common causes of ESLD include infection (e.g., acute or chronic hepatitis), toxic effects (e.g., alcohol, medications), disorders of metabolism (e.g., hemochromatosis, Wilson's disease), tumors (primary or metastatic), and malformations (e.g., primary biliary atresia). Liver tra...
The specific causes of primary liver cancer in this study included hepatitis B, hepatitis C, alcohol consumption and other causes. The International Classification of Diseases (ICD-10) criteria was used to define primary liver cancer and the various specific causes of liver cancer (C22.0–C22.4,...
HCV infection, autoimmune hepatitis, primary biliary cirrhosis, acute alcoholic hepatitis, alcoholic fatty liver, unspecified alcoholic liver damage, alcoholic cirrhosis, alcohol use disorder, and chemical dependency treatment (ICD-9 and ICD-10 diagnostic codes are provided in eTable 1 in ...
Non-alcoholic fatty liver disease (NAFLD) is defined as excessive hepatic steatosis in the absence of specific causes (i.e., alcohol consumption, hepatitis B or C infection) [6]. Approximately 25% of adult population is affected by NAFLD currently, with worsening epidemic in recent decades coin...
NAFL, the first stage of NAFLD, can progress to nonalcoholic steato- hepatitis (NASH)4,5. Furthermore, some patients with NASH develop liver cirrhosis and hepatocellular carcinoma (HCC). Obesity, metabolic syndrome, diabetes and hypertension are recognized risk factors for NAFL and NASH1,6,7,...
The recruited volunteers gave informed consent for data linkage to medical reports, which allowed the researchers to collect the available ICD codes. After excluding individuals with pathological alcohol consumption and viral hepatitis, the cohort was left with >17,000 individuals with Pi∗MZ, >800...
We then excluded individuals with chronic viral hepatitis diagnosis (ICD-10 codes B18.0, B18.1, B18.2, B18.8, B18.9, B19.0, B19.9) from the analyses (Supplementary Table 1). Liver Fat Content Measurement in the UK Biobank We used derived magnetic resonance imaging (MRI) liver fat, as ...