To develop a liver function-related risk prediction tool to identify acute-on-chronic liver failure patients at greatest risk of in-hospital mortality. The
Another interesting topic are age-related changes in the function of the GH/GHR system, in particular the question of why GHR deficiency leads to juvenile hypoglycemia that normalizes during puberty. Finally, it will be interesting to see to what extent altered liver functions in GHR deficiency ...
In order to find differential expressed genes between groups of interest, Welch’s t-tests were done as implemented in the scanpy function rank_genes_groups with the parameters method=”t-test” and n_genes=19258. First, this was done between cell types, considering 2n and 4n hepatocytes toge...
48,49. Rescuing the normal liver function and prevention of long-term radiation toxicity demands understanding of the molecular changes induced by radiation in normal liver cells which could then be evaluated for therapeutic interventions.
Genetic loss-of-function studies confirm a functional role of HRH2 in hepatocarcinogenesis To confirm that the observed inhibitory effects of nizatidine on hepatocarcinogenesis are mediated by its target HRH2, we performed genetic loss-of-function studies in animal and cell-based models. First, we ...
Citation:Koizumi A, Kaji K, Nishimura N, Asada S, Matsuda T, Tanaka M, Yorioka N, Tsuji Y, Kitagawa K, Sato S, Namisaki T, Akahane T, Yoshiji H. Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease.World J Gastroente...
, n-6 and n-3 FA families, as well as the n-6/n-3 ratio. For additional information about methods and measures, see [3,10]. A Student t test was performed using the t.test function in R for testing the dietary effect in each of the three FA classes....
FoxO function is essential for maintenance of autophagic flux and neuronal morphogenesis in adult neurogenesis Neuron, 99 (2018), pp. 1188-1203.e1186 Google Scholar 24 S. Wang, P. Xia, G. Huang, P. Zhu, J. Liu, B. Ye, Y. Du, Z. Fan FoxO1-mediated autophagy is required for NK ce...
the patient’s liver function tests began to rise again, thus further doses of intramuscular and oral paliperidone were stopped and the patient was started on haloperidol, with normalization of liver function tests. Scoring of this case using the Naranjo scale indicated a probable association between...
Endoplasmic reticulum (ER)-mitochondria contacts are critical for the regulation of lipid transport, synthesis, and metabolism. However, the molecular mechanism and physiological function of endoplasmic reticulum-mitochondrial contacts remain unclear. He