( P Comparison: binary diagnosis versus fibrosis classification, respectively, overall accuracy: CirrhoMeter2G: 79.2% versus 88.8% ( P P =0.127); positive predictive value for cirrhosis by Fibroscan: Youden cutoff (11.1 kPa): 49.1% versus cutoffs of F3/4 (17.6 kPa): 67.6% and F4 classes ...
For example, HCV coinfection adversely affects liver fibrosis in HBV patients, increasing the number of decompensated cirrhosis patients[46]. CONCLUSION Cirrhosis and other chronic liver diseases remain a substantial health burden in China, with the increase of population and the aging of population....
The incidence of death from any cause and of development of the first decompensation of cirrhosis was calculated.Results:Overall mortality rate was 1.63 [95% confidence interval (CI) 1.06-2.49] per 100 person-years. The adjusted hazard ratio [AHR (95% CI)] of baseline fibrosis (per stage ...
Objective To investigate the value of real-time ultrasound elastography(RTE) in diagnosing liver fibrosis in patients with chronic liver disease.Methods Totally 88 patients who suffered chronic viral hepatitis underwent RTE.The elastic strain ratio of liver tissue to intercostal muscle tissue was measure...
Cirrhosis is a generic term used to describe chronic liver disease involving diffuse parenchymal necrosis, active formation of connective tissue leading to fibrosis, and nodular regeneration of liver resulting in disorganization of the hepatic lobular and vascular architecture. ...
Hedgehog (Hh) signalling regulates hepatic fibrogenesis. MicroRNAs (miRNAs) mediate various cellular processes; however, their role in liver fibrosis is unclear. Here we investigate regulation of miRNAs in chronically damaged fibrotic liver. MiRNA profil
Decompensated cirrhosis is defined as stage 4 liver fibrosis with the presence of one or several complications of portal hypertension including variceal bleeding, hepatic encephalopathy, ascites, spontaneous bacterial peritonitis (SBP), and/or hepatorenal syndrome. ...
Sorafenib—a broad kinase inhibitor—is a standard therapy for advanced hepatocellular carcinoma (HCC), and has been shown to exert anti-fibrotic effects in liver cirrhosis, a precursor of HCC. However, the effects of sorafenib on tumor desmoplasia—and its consequences ...
(NASH) characterized by lobular inflammation, and hepatocyte ballooning2. Up to one third of patients with NAFLD progress to advanced fibrosis, leading to increased liver-related mortality owing to decompensated cirrhosis or development of hepatocellular carcinoma3. Accumulating evidence indicates that ...
Improved on-treatment fibrosis-4 during antiviral therapy and lower hepatocellular carcinoma risk in cirrhotic patients with hepatitis B Joo Hyun Oh ,Yewan Park &Seung Woon Paik Article 06 June 2023|Open Access The meta-analysis and systematic review of prevalence and clinical anatomy of the arc of...