In a phase III, randomized controlled trial, 966 patients with biopsy-confirmed NASH and liver fibrosis (stage F1B, F2 or F3) were randomly assigned to receive a once-daily dose of 80 mg resmetirom, 100 mg resmetirom or placebo for 52 weeks. Resolution of NASH with no worsening of...
Correction: Patients with stage 3 compared to stage 4 liver fibrosis have lower frequency of and longer time to liver disease complications (PLoS One (2018) 13:5 (e0197117) DOI: 10.1371/journal.pone.0197117)doi:10.1371/journal.pone.0199402Page Axley...
we analysed the expression of miR-378a-3p and its target,gli3, in non-tumour and tumour regions of liver tissues obtained from 18 patients with hepatocellular carcinoma (HCC) and advanced fibrosis (stage F3 or F4). The level of miR-378a-3p was lower in tumour tissues (0.82±0.185) than...
Liver fibrosis, as described in clinical pathology reports, was grouped into 3 severity levels: no fibrosis (stage 019), mild fibrosis (stage 119: minimal fibrosis or fibrous expansion of some portal areas, with or without short fibrous septa), or moderate to severe fibrosis (stages 2-619: ...
Liver fibrosis is common, particularly in individuals who are infected with human immunodeficiency virus (HIV). HIV-infected individuals have excess congestive heart failure (CHF) risk compared with uninfected people. It remains unknown whether liver fibrosis stage influences the CHF risk or if HIV ...
Three different endpoints were studied according to liver fibrosis stage, namely significant fibrosis (S2 to s4), extensive fibrosis (S3 to S4) and cirrhosis (S4). With liver biopsy as the gold standard, ROC curves were delineated for different endpoints. The area under the ROC curves reflected...
Factors associated with hepatic fibrosis in patients with chronic hepatitis C: a retrospective study of a large cohort of U.S. patients. To determine the risk factors for stage 3 and 4 fibrosis in a large cohort of U.S. patients with chronic hepatitis C (CHC). Multiple host and viral fac...
For predicting stage ≥1, ≥2, and ≥3, the area under receiver operating characteristic curve (AUC) of MSI was largest among all parameters; for stage 4 AUC of TTP was largest.ConclusionDCE-MRI has the potential to dynamically stage progression of liver fibrosis. J. Magn. Reson. Imaging ...
Liver fibrosis is a wound-healing response characterized with the accumulation of extracellular matrix (ECM). And hepatic stellate cells (HSCs) are the principal cell source of ECM. NR4A2 (Nurr1) is a member of orphan nuclear receptor NR4A family and act
158,159 Patients treated with 0.4 mg of Semaglutide had improvements in fibrosis stage compared with patients in the placebo group (43% vs. 33%) in a phase 2 clinical trial (NCT02970942).160,161,162 Given the potent effects of Semaglutide, several clinical trials are underway to ...