Knowing how to feed dogs with liver disease is important. Your vet will help you develop an evidence-based plan to treat your dog's liver.
Conventional biochemical markers have limited usefulness in the prediction of early liver dysfunction. We, therefore, tried to find more useful liver failure biomarkers after liver resection that are highly sensitive to internal and external challenges i
Dogs with extensive fibrosis and remodeling develop portal hypertension and ascites. Rare cases with fulminant hepatic failure display centrilobular hemorrhagic necrosis due to vascular inflammation and loss of sinusoidal endothelium. Widespread distribution of petechia ...
Kelly JH, Koussayer T, He DE, Chong MG, Shang TA, Whisennand HH, et al: An improved model of acetaminophen-induced fulminant hepatic failure in dogs. Hepatology. 1992, 15 (2): 329-335. 10.1002/hep.1840150225. Article CAS PubMed Google Scholar Jollow DJ, Mitchell JR, Potter WZ, Da...
In contrast, diffuse and severe chronic hepatitis, as seen in dogs, usually leads to loss of hepatic parenchyma and architectural distortion of the liver as a consequence of fibrosis and nodular parenchymal regeneration. This process can proceed to end-stage hepatic disease with hepatic failure and...
During the post-absorptive state, as seen in dogs, approximately 50% of intestinal ammonia originates from metabolism of glutamine in small intestine, 21% comes from breakdown of urea in the large intestine while 5% comes from glutamine metabolism in large intestine9. The kidneys also play a ...
The liver is the most important metabolic organ in the body. While mouse models and cell lines have further deepened our understanding of liver biology and related diseases, they are flawed in replicating key aspects of human liver tissue, particularly i
Chronic liver failureresults from progressive destructive processes, such as fibrosis or inflammation, or a combination of the two. The hallmarks of chronic liver failure in dogs are fibrosis and nodular regeneration, but other species are more prone to a fibrotic response alone. The progressive ...
Drugs or their intermediary metabolites can have a toxic effect on the liver, making drug induced liver injury the leading cause of acute liver failure in the United States alone and the major reason for drug withdrawal from the market [132]. The search of in vitro models that could predict...
Hepatic encephalopathy (HE), a serious complication of both chronic liver disease and acute liver failure, is arguably the most clinically relevant entity affecting the crosstalk between liver immunity and the CNS. HE manifests in a wide spectrum of neurocognitive abnormalities, ranging from acute sev...