The healthy liver is mitotically quiescent, but following toxic damage or resection the cells can rapidly enter the cell cycle to restore liver mass and function. During this process of regeneration, epithelial and non-parenchymal cells respond in a tightly coordinated fashion. Recent studies have ...
termed neddylation, participates in many cellular processes and is aberrant in various pathological diseases. Its relevance to liver function and failure remains poorly understood. Herein, we show dysregulated expression of NAE1, a regulatory subunit of the only NEDD8 E1 enzyme,...
Summary This review discusses the function and localisation of lymphocytes resident within the human liver, under both physiological and pathological conditions. Through description of the mechanisms that mediate lymphocyte recruitment into tissues, this article explains how hepatic endothelial and epithelial ...
Silymarin, an extract from milk thistle seeds, has been used for centuries to treat hepatic conditions. Preclinical data indicate that silymarin can reduce oxidative stress and consequent cytotoxicity, thereby protecting intact liver cells or cells not yet irreversibly damaged. Eurosil 85®is a propr...
The liver segmentation system, described by Couinaud, is based on the identification of the three hepatic veins and the plane passing by the portal vein bifurcation. Nowadays, Couinaud's description is the most widely used classification since it is better suited for surgery and more accurate for...
Both of the doses of ATV or FTZ referenced from Drug Description of manufacturer for clinical treatment in human, and the doses of ATV or FTZ for mice in this study calculated according to the allometric calculation from the daily dose for human indicated in the instruction of Drug Description...
than 200 were filtered. Batch effects were mitigated across two sections using the harmony [12] function, then 2 spatial sections were normalized and scaled by the function SCTransform [13]. And the integrated data of two sections were subjected to subsequent analyses. A comprehensive description ...
it is known that liver function decreases with age26and that the liver ages at the cellular level, which is for example associated with low-grade inflammation27. There is less evidence that the liver undergoes clear macroscopic changes that could be captured by MRI images28, but it has been ...
Cases were defined using hospital or registry records (ICD-9 or ICD-10). Controls were defined as individuals without a known history of cirrhosis. A full description of the cohorts and case and control definitions is provided inSupplementary Informationand Supplementary Table1. Details on genotyping...
One chapter is devoted to the liver and the many attempts to evaluate its functions. Admittedly, the present liver function tests leave much to be desired, and newer biochemical knowledge is necessary to evaluate all of the dozens of functions which the liver has. A discussion of the possible...