The present study examined the risk of development of cirrhotic liver disease and the risk of death in a cohort diagnosed with pure fatty liver without inflammation. Methods: A total of 215 patients who had a liver biopsy performed during the period 1976–1987 were included in the study. The...
Liver disease is common in the US. About 4.5 million adults (1.8%) are diagnosed with some form of liver disease, but more than 100 million actually have it. They just don’t know. Liver disease is the ninth most common cause of death in the U.S. (more than 55,000 deaths a year...
First, because of its population-based observational study design, the results should be interpreted cautiously. Second, using FLI as a surrogate marker of NAFLD cannot accurately quantify the presence and amount of steatosis37. Although liver biopsy is considered the gold standard for diagnosing ...
Non-invasive assessment of hepatic disease severity represents a relevant issue to further improve clinical management and therapeutic treatment. We retrospectively compared the diagnostic and prognostic performance of different non-invasive tools (LiMAx, transient elastography (TE), and biomarkers) in ...
particularly in sub-Saharan Africa,Southeast Asia, and China. As a result, HCC is the fourth leading cause of cancer-related death globally. Liver cancer, particularly HCC, generally is more common among men than women and among Blacks than whites. It also occurs most frequently in persons wit...
Since liver biopsy and HVPG are invasive methods implying risks, the current guidelines recommend that patients with suspicion of ACLD should initially be assessed using non-invasive methods [19].The simplest non-invasive methods are the serological non-invasive tests (NITs) such as the aspartate ...
Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an uncommon drug adverse reaction that can develop to conditions spanning from asymptomatic liver laboratory abnormalities to acute liver failure (ALF) and death. The cellular and molecular mechanisms involved in DILI...
When working properly, the liver's main job is to filter the blood coming from the digestive tract, before passing it to the rest of the body. (Photo Credit: WebMD) Chronic liver disease/cirrhosis (a disease where your liver is permanently scarred) is the 10th leading cause of death in...
Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among patients with colorectal cancer (CRC). Although immunotherapy has demonstrated encouraging outcomes in CRC, its benefits are minimal in CRLM. The complex immune landscape of the hepatic tumour microenvironment is ess...
1 Up to one-third of patients with MASLD develop progressive steatohepatitis and fibrosis, which can lead to cirrhosis, hepatocellular carcinoma, and death.2,3 Yet, approved medications that effectively and safely reverse steatosis, inflammation, and fibrosis are lacking. Aspirin may represent a ...