These findings are best explained by a constant fractional clearance of bile acids by the liver. We conclude that the serum conjugated bile acid determination as a test of liver cell function is not sensitive enough to identify all cases of biopsy-proven liver disease....
This can be explained by increased vulnerability of the liver to injuries such as oxidative stress or cytokines, as reflected by higher BMI, AST, ALT, and HOMA-IR levels in individuals with a high NAFLD liver fat score (> − 0.640) compared with those with low NAFLD liver fat score...
Liver biopsy has been the reference standard for diagnosing the etiology of liver cirrhosis5. However, biopsy is invasive with an incidence of moderate to major procedure-related complications of approx. 1.2% and a mortality rate of 0.4%. Other limitations of liver biopsy include inter- and intra...
Fasting and postprandial (stimulated) serum conjugated bile acids (CBA) were measured by a solid-phase radioimmunoassay in 329 patients undergoing liver biopsy, and the results were analyzed for 231 who fitted into 10 diagnostic categories. In healthy volunteers the mean fasting CBA of 1.8±0.7 μ...
NAFLD is clinically diagnosed if the liver consists of > 5% fat, as monitored by liver imaging or biopsy in the absence of secondary causes of fat accumulation such as chronic alcohol abuse (defined as more than one drink per day for women or two for men) (Carr et al.2016). NAFLD...
The different opinions concerning the value of fine-needle biopsy may partly be explained by divergencies in results between examiners. 103 coded fine-needle aspiration biopsy smears were stained by the May-Grnwald-Giemsa''s method and examined independently by two investigators by light microscopy....
In the setting of advanced disease, and especially if systemic therapy is considered, a biopsy is very valuable. As described in the pathology section, diagnosis of HCC may include variants, as well as possible combined cholangiocarcinoma plus HCC, the treatment of which will differ from that ...
This finding is logically explained by the biological difference between the samples compared in the two studies: in the present study, we compared a growing HepG2 cell line with a stationary liver biopsy sample, while Costantini et al. [13] compared two cell lines, each dividing at a ...
N. et al. Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy. World J Hepatol 8, 673–684, https://doi.org/10.4254/wjh.v8.i16.673 (2016). Article PubMed PubMed Central Google Scholar Puri, P. et al. A lipidomic analysis of nonalcoholic ...
secretion, as regulated by cancer cell-secreted fibroblast growth factor-binding protein 1 (FGFBP1). This mechanism stimulates epithelial–mesenchymal transition (EMT) and induces vessel co-option that results in bevacizumab resistance in CRLM models [114]. Therefore, HSCs play an important role in...