Liver pathology is a key diagnostic procedure in assessing liver disease. This chapter outlines a basic approach to liver biopsy assessment by evaluating architecture, portal tracts, parenchyma and a routine set of special stains. Information is provided about the differentiation of different patterns ...
While liver biopsy remains the gold standard for assessing liver pathology, its invasiveness and potential complications necessitate the development of non-invasive diagnostic methods. Advances in serological markers and imaging technologies strive to maintain diagnostic precision while reducing patient discomfort...
This chapter outlines practical approaches for rapid on-site assessment during fine needle aspiration or biopsy of liver lesions. It is important to classify the lesions into primary hepatocyte lesions, primary bile duct lesion lesions, and metastatic tumors. Well-differentiated hepatocellular carcinoma or...
liver biopsy. 3.4 Cirrhosis This is not well documented but is not uncommon. End-stage pathology is the same as for other specific liver condition or for senile change. The most likely clinical presentation is chronic, progressive weight loss. Diagnosis is confirmed by biopsy. Supportive treatment...
Fig. 4 outlines a clinical algorithm for the screening, evaluation, and management of pediatric MASLD, emphasizing the role of ALT thresholds, imaging modalities, and lifestyle modifications, as well as criteria for GI referral and consideration of liver biopsy. 8. Question 6: how effective is ...
[69]. Additionally, exercise has been shown to ameliorate metabolic abnormalities such as insulin resistance and hypertriglyceridemia to some extent [75,76]. Evidence from liver biopsy confirms that exercise can mitigate or improve hepatitis in NASH patients [77]. The primary mechanism through which ...
To exclude diffuse micrometastasis, a liver biopsy was obtained and displayed significant cholestasis but no tumor tissue. The patient died 3 months later without evi- dence of metastatic tumor spread. An autopsy was not performed. Case 3 A 72-year old man presented with non-specific abdominal ...
The differentiation of a malignant from benign lesion on imaging can often negate the need for biopsy. Ultrasound is currently the main screening tool for suspected liver pathology, and is ideally suited for evaluation of hepatic lesions in children due to their generally small size. With ...
If validated, this exciting approach could be utilised as a potential plasma biomarker of liver fibrosis progression that negates the need for biopsy. Furthermore, this study proposed that the source of circulating cell-free DNA is likely to be dying/damaged hepatocytes, this interesting fi...
As used herein, a “biological sample” can be obtained from any source, including a body fluid sample such as serum, blood, blood cells (e.g., white cells), plasma, sputum, urine or a tissue sample (e.g. liver tissue sample) or fine needle biopsy samples, peritoneal fluid, and ...