Chart review was done to note demographics, co- morbid illnesses, physical characteristics, hepatomegaly, aspartate/alanine aminotransferase (AST/ALT) levels, albumin, lipid levels, alkaline phosphatase, prothrombin time, and partial thromboplastin time. Data obtained were analyzed using the statistical ...
5a–c) and exhibited a marked elevation in circulating levels of ALT and AST despite suppression of serum and hepatic triglycerides (Fig. 4a–d and Extended Data Fig. 5d). Compared with WT mice, the homozygous knock-in mice exhibited ~eightfold and ~tenfold increase in esterified and free ...
as theRBFOX2gene has a complex architecture with multiple promoters19(Fig.6a). Expression ofRBFOX2in the human hippocampus or aortic smooth muscle is driven by one proximal and one distal promoter, whose activity levels are similar. In hepatocytes, the ...
Chart review was done to note demographics, co-morbid illnesses, physical characteristics, hepatomegaly, aspartate/alanine aminotransferase (AST/ALT) levels, albumin, lipid levels, alkaline phosphatase, prothrombin time, and partial thromboplastin time. Data obtained were analyzed using the statistical ...
AST/ALT, aspartate/alanine aminotransferase; CDT, carbohydrate-deficient transferrin; GGT, gamma-glutamyltransferase; MCV, mean corpuscular volume. Equally important may be the possible synergy between alcohol consumption and the presence of metabolic risk factors for liver disease progression,75,83 with ...
NAFLD was characterized by abnormal iron metabolism accompanied by down-regulation of Cav-1 in liver.aFlow chart of mouse NAFLD model construction.bLine chart of changes in body weight of mice within 12 weeks (n = 7).cAccumulation of fat in liver of mice.dSerum levels of ALT, AST, ...
b Percent survival chart of WT mice after saline, NAC, or SCM-198 treatment given at 0.5 or 24 hpi (n = 10 per group). The p-values were determined using the Log-rank test. c Serum ALT and AST levels were measured at 48 hpi in WT mice treated with saline, NAC, or SCM-...
AST, a significant reduction in necrotic area of liver tissue, significant increases in the protein expression levels of SOD and Nrf2, and a significant reduction in MDA (all P<0.05); there were significant differences in the protein expression levels of LC3Ⅰ/Ⅱ, Beclin1, P62, p-Akt, and...
The clinical data were retrospectively extracted from medical records, including baseline data [(age, sex, height, weight, alcohol consumed, hypertension, type 2 diabetes mellitus (T2DM), albumin (ALB), total bilirubin (TBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total ...
While there are simple indicators available, such as the AST to-platelet ratio index (APRI) and Fibrosis-4 (FIB-4) index, to assess liver fibrosis, there remains a dearth of effective and straightforward indicators to identify liver steatosis specifically in non-obese populations [14]. This ...