functional readouts of TDP-43 proteinopathy. Additionally, a dysregulation of autophagy and senescence markers was observed in this condition. In a preliminary drug screening approach with autophagy-promoting drugs, namely rapamycin, lithium carbonate and metformin, only rapamycin prevented ARS-induced ...
Drug-induced lithium toxicity in the elderly: a population-based study. J Am Geri- atr Soc. 2004;52(5):794-798.Juurlink DN, Mamdani MM, Kopp A, Rochon PA, Shulman KI, Redelmeier DA. Drug-induced lithium toxicity in the elderly: a population-based study. J Am Geriatr Soc. ...
of the drug are carefully monitored include slight muscular weakness, thirst, and excessive urination. The major difficulty with lithium is that a fairly high concentration of the ion is needed in the blood (0.5_x0002_1.0 mmol/L) for maintenance, higher for acute mania. Toxic symptoms (which...
Lithium carbonate has been observed to induce neutrophilia in psychiatric patients and has been used in a number of childhood neutropenic disorders. We tried lithium carbonate in three children with glycogenosis Ib to see if the drug would alleviate the neutropenic complications of the disorder. Mean...
in the sera of newborn mice, but a previous study employing the same drug treatment strategy has demonstrated that lithium can reach the blood of newborn mice via mother’s milk and reported detailed concentrations of serum fluoxetine and its metabolite during and after the treatment [21,22,23...
Adnan A. Badwan, in Profiles of Drug Substances, Excipients and Related Methodology, 2015 2.1 Drug-Free Base and Its Hydrochloride Salt 2.1.1 Method 1 [4,7,8] 2-Fluorobenzyl bromide (1) is reacted with cyclopropyl cyanide (2) in a mixture of metallic magnesium and anhydrous diethyl ether...
Therefore, cardiotoxicity becomes the most important cause for the recall of prescription drugs [26]. It accounts approximately half of all drugs withdrawn in the last two decades [26]. For example, the obesity treatment drug sibutramine and the antidiabetic drug rosiglitazone were both recalled ...
Two batches of drug-naïveAkt1+/−female mice and their WT littermate controls were used to evaluate behavioral performance and protein expression after subchronic lithium or saline administration. All mice were handled and weighed daily at least 1 week before the administration. According to prev...
A 52-year-old woman with bipolar disorder developed renal microcysts during long-term lithium treatment [ details of drug administration and duration of therapy not stated ]. The woman, who had a history of type 2 diabetes mellitus, multiple sclerosis, and hypothyroidism, underwent renal ...
Background It has been estimated that about 10 per cent of children between 6 and 20 years of age suffer from migraine, and that children with migraine lose one and a half weeks more schooling per year than their peers. Prophylactic drug... S Victor,S Ryan - 《Cochrane Database of Syste...