These drugs block the enzyme dipeptidyl peptidase-4 (DPP-4) which breaks down the incretins. This allows the naturally occurring incretins to act for longer and thereby bring down the blood glucose levels. It will also enhance the other effects of the incretins. ...
Categories: Active Pharmaceutical Ingredients > Circulatory System Drugs Vildagliptin (LAF-237; NVP-LAF 237) inhibits DPP-4 with IC50 of 2.3 nM.IC50 Value: 2.3 nM[1]Target: DPP-4in vitro: Vildagliptin is an N-substituted glycyl-2-cyanopyrrolidine (figure 2). It is a potent competitive and...
“Neuroprotection or Neurotoxicity of Illicit Drugs on Parkinson’s Disease”by Carla Ferreira, Catarina Almeida, Sandra Tenreiro and Alexandre QuintasLife 2020, 10(6), 86; https://doi:/10.3390/life10060086 Metabolites: “Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment”by...
Latentautoimmune diabetes of adulthood (LADA) is a new term for patients whose diabetes more closely resembles type 1 diabetes, but don't quite have all the symptoms. Often misdiagnosed as type 2 diabetes, LADA – also sometimes called type 1.5 diabetes – is believed to be a slowly progress...
While speaking on the motion, Bulanauca says we cannot have an offender’s name in the register for all of his or her life and we should give them a chance to change. He says we should delete the establishment of this register and give people time to chan...
This study aimed to examine the reporting quality of existing economic evaluations for negotiated glucose-lowering drugs (GLDs) included in China National Reimbursement Drug List (NRDL) using the Consolidated Health Economic Evaluation Reporting Standard
For the rest of our coverage, key new drugs included in the NRDL are: (1)SinoBioharm: four oncology drugs (imatinib, dasatinib, decitabine and palonostrone)and key hypertension drug Yilunping; (2) Hengrui: dexmedetomidine (key anesthesiadrug), imrecoxib (Hengrui’s first novel drug), febusta...
When an accepted treatment doesn’t exist, or has failed, clinical trials for unreleased drugs can offer additional options. Some options: Clinical Trial Select FindMeCure.com Antidote.me(I used to be on their advisory board – seemy page with their search widget) ...
SONG OF THE SUMMER BLACKPINK “How You Like That” (WINNER) Cardi B ft. Megan Thee Stallion –“WAP” DaBaby ft. Roddy Ricch “Rockstar” DJ Khaled ft. Drake “Popstar” Doja Cat –“Say So” Dua Lipa –“Break My Heart” Harry Styles –“Watermelon Sugar” ...
CD242 ICAM-4 42 kDa Erythrocytes Adhesion, Landsteiner-Wiener blood group CD11a/CD18,CD11b/CD18, CD51,CD29, integrin β5 CD243 MDR-1, p170, P-gp 180 kDa Stem cells, small intestine, kidney stem cells Efflux transporter of various drugs CD244 2B4, p38 70 kDa NK cells, T cell su...