A 30-year-old woman developed fatigue and jaundice. She had hypertension and nephrotic syndrome and had taken furosemide and lisinopril 10mg/day for 8 months. She had previously taken enalapril, lisinopril, and quinapril without adverse reactions. The liver enzyme abnormalities continued to worsen and...
23 The ranking of tissue retention was quinaprilat > lisinopril > enalaprilat > captopril and this ordering reflects both the binding affinity and lipophilicity of these particular ACE inhibitors.23 These tissue-based studies, however, have yet to be correlated with head-to-head clinical effect ...