2–5). The topoisomerase 1 poison, camptothecin (CPT), induced a similar level of CHK1 phosphorylation in parental and KO cells (Fig. 1a and Supplementary Fig. 1d–f), indicating that 53BP1 KO cells retained normal DNA damage response, consistent with the idea that 53BP1 is not a ...
Current literature studies on JP-8 and other jet fuels are limited for the assessment of reproductive and developmental toxicity risk to humans. Although animal studies on the reproductive effects of JP-7 were not reported, in one chronic study in mice exposed to 1,000 or 5,000 mg/m3 of ...
100 mg/day, based on body surface area (BSA) comparison) have revealed no significant increase in tumor incidence. A 2-year carcinogenicity study conducted in mice employing diclofenac sodium at doses up to 0.3 mg/
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While simultaneously instituting treatment, contact a regional poison center to obtain updated information and advice on individualizing the recommendations that follow. Institutesupportive care, including establishment of intravenousaccess, maintenance of the airway, and electrocardiographic monitoring. ...
Conventionally, the biological method using mice has been adopted as the official method for the quantitative determination of puffer-fish poison.1The mouse bioassay is used for the analysis of many marine toxins, including TTX, but does not evaluate TTX itself. Moreover the method tends to lack...
which have been demonstrated to be tumorigenic in nude mice66, were responsible for the formation of our MCCs. Further studies would be needed to confirm this. Notably, ALI multilayered mono-cultures up-regulated the expression of fibronectin overtime (Fig.3). It is known that fibronectin stimu...
N-[2-(Dimethylamino)ethyl]-2,6-dimethyl-1-oxo-1,2-dihydrobenzo[ b]-1,6-naphthyridine-4-carboxamide (SN 28049) is a potent topoisomerase II poison being developed to treat solid tumours. A reliable and sensitive LC–MS method has been developed and validated for the determination of SN ...
“Botulinum Toxin: A Deadly Poison Sheds Its Negative Image” Annals of Internal Medicine, 125:616-617, Oct. 1, 1996. Henry S. Sacks et al, Clostridium botulinum Type E Toxin: Effect of pH and Method of Purification on Molecular Weight, Applied Microbiology, Sep. 1974, p. 374-382, ...
reduces the negative charges on the cell wall of the bacteria, crosses through the cell membrane, weakened by the surfactant, and acidifies the cytoplasm of the bacteria. The antimicrobial active can then pass more easily through the weakened cell wall, and more efficiently poison the bacteria....