there are no teratogenicity studies in non-rodents (e.g., rabbits). Theophylline was not shown to beteratogenicin CD-1 mice at oral doses up to 400 mg/kg, approximately 2.0 times the human dose on a mg/m2basis or in CD-1 rats at oral doses up to 260 mg/kg, approximately 3.0 ti...
Brodifacoum for the second-generation anticoagulant rodenticides can be a few days on a variety of rodent poison have Lethal effects. Applicable to urban, rural, residential, hotels, restaurants, warehouses, vehicles, ships and field the Kind of environment to kill mice. Note: 1.The toxic agen...
For additional information about overdose treatment, contact a poison control center (1-800-222-1222). Contraindications for Diclostream Diclofenac Sodium is contraindicated in the following patients: Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to diclofenac or any co...
Conventionally, the biological method using mice has been adopted as the official method for the quantitative determination of puffer-fish poison.1The mouse bioassay is used for the analysis of many marine toxins, including TTX, but does not evaluate TTX itself. Moreover the method tends to lack...
2–5). The topoisomerase 1 poison, camptothecin (CPT), induced a similar level of CHK1 phosphorylation in parental and KO cells (Fig. 1a and Supplementary Fig. 1d–f), indicating that 53BP1 KO cells retained normal DNA damage response, consistent with the idea that 53BP1 is not a ...
N-[2-(Dimethylamino)ethyl]-2,6-dimethyl-1-oxo-1,2-dihydrobenzo[ b]-1,6-naphthyridine-4-carboxamide (SN 28049) is a potent topoisomerase II poison being developed to treat solid tumours. A reliable and sensitive LC–MS method has been developed and validated for the determination of SN ...
which have been demonstrated to be tumorigenic in nude mice66, were responsible for the formation of our MCCs. Further studies would be needed to confirm this. Notably, ALI multilayered mono-cultures up-regulated the expression of fibronectin overtime (Fig.3). It is known that fibronectin stimu...