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1、通过检测两名肝癌患者(编号分别为HCC-041和HCC-075),间隔1周抽取他们血液分别作CTC-iChip和血液AFP检测,发现CTC评分(CTC-iChip检测获得的指标)在两个患者都很高,而血液AFP在HCC-075患者体内没有检测到,说明CTC-iChip系统的特异性更高(图4A)。 2、两个肝癌患者(编号分别为HCC-058和HCC-060)接受外科肿瘤切...
参考文献 1. Kalinich M, et al. (2017) An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma. Proc Natl Acad Sci USA, 114(5):1123-1128. 2. Karabacak NM, et al. (2014) Microfluidic, marker-free isolation of circulating tumor cells f...
liquid biopsyBreast cancer is the most common cancer among women worldwide. Due to its complexity in nature, effective breast cancer treatment can encounter many challenges. Traditional methods of cancer detection such as tissue biopsy are not comprehensive enough to capture the entire genomic ...
Advances in qPCR-based liquid biopsy for cancer detection & its applicationsCancer is a leading cause of death globally, killing nearly 10 million people in 2020, with breast cancer, lung cancer and colon cancer representing the three most common types 1 . Diagnostic strategies focused on early ...
Sensitive and robust liquid biopsy-based detection of PIK3CA mutations in hormone-receptor-positive metastatic breast cancer patients Br J Cancer, 126 (3) (Feb 2022), pp. 456-463, 10.1038/s41416-021-01601-9 in eng Google Scholar [46] M.J. Higgins, et al. Detection of tumor PIK3CA status...
This review discusses the liquid biopsy techniques currently under investigation and their potential for early-stage detection of solid carcinomas. Impact of earlier cancer detection Most cancers can be classified according to the stage of disease, a measure of how widely it has spread in the ...
Multicancer early detection test could detect cancer with an AUC of 0.94 for all cancer types and stages. A liquid biopsy-based multicancer early detection (MCED) test could detect 12 types of cancers, including low DNA-shedding cancers and early-stage cancers, according to...
general noncoding RNAs have been correlated with breast cancer prognosis, miR-34a being significantly downregulated in breast cancer compared to healthy controls68,69,70,71. The other abundant tumor-derived circulating component derived from a liquid biopsy is represented by the ctDNA. In the ...
The development of detection technology has provided basis for liquid biopsy. Nowadays, liquid biopsy has received enormous attention as it can serve as a minimally invasive approach for early detection of cancer [12]. Liquid biopsies mainly include cfDNA, CTCs, and exosomes. Also, sputum, bronchoa...