The NLRP3 inflammasome, a reactive oxygen species-sensitive multiprotein complex, regulates IL-1 maturation via caspase-1 and plays an important role in the pathogenesis of inflammation-related disease. LOX catalyzes the oxidation of fatty acids and is involved in the regulation of the innate ...
15-lipoxygenase is involved in the generation of specialized pro-resolving lipid mediators that play essential roles in resolution and inflammatory responses. Here, we investigated anti-inflammatory role of Alox15 in skin homeostasis. We demonstrated that knockout (KO) of Alox15 led to hair loss ...
SLO exists in three isoforms (sLO-1, sLO-2 and sLO-3) that share homologous sequences.60 In the latter part of the twentieth century, mammalian lipoxygenases became of great interest pharmaceutically due to their role in inflammatory processes.93 Plant LOs catalyze the conversion of lineolic ...
In mice, there is an orthologous enzyme for each human ALOX paralog but the catalytic properties of human and mouse ALOX orthologs show remarkable differences. ALOX inhibitors are frequently employed for deciphering the biological role of these enzymes in mouse models of human diseases but owing to...
However, the role of LM in the induction of trained immunity has not yet been comprehensively investigated. We used an established in vitro model of trained immunity12, in which human peripheral blood monocytes were exposed to β-glucan or BCG for 24 h and left to rest for the following ...
Lipoxygenases (LOX) are non heme iron-containing dioxygenases. These enzymes convert unsaturated fatty acids to epoxides; for example, the synthesis of leukotrienes from arachidonic acid. They play an important role in cell proliferation, differentiation and inflammation; and have been implicated in in...
Interestingly, these lipid mediators are involved in activation of pro-inflammatory signal transduction pathways such as the nuclear factor κB (NF-κB) pathway, which illustrates the intimate link between lipid signaling and transcription factor activation. The identification of the role of arachidonic ...
Kantarci, A, Van Dyke, TE (2003) Lipoxins in chronic inflammation. Crit Rev Oral Biol Med 14: pp. 4-12 CrossRef Kim, E, Rundhaug, JE, Benavides, F (2005) An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis. Oncogene 24: pp. 1174-87 CrossRef Kinzig, A, He...
It has been shown that 12/15-LO is involved in the regulation of vascular permeability during ALI. To test whether 12/15-LO participates in leukocyte recruitment into the lung, we investigated the role of 12/15-LO in mouse models of lipopolysaccharide (LPS)-induced pulmonary inflammation and ...
Finally, 8, 9- and 11-HETE have also been detected in human skin, although their exact origin has not yet been fully elucidated [22,62]. Show abstract Ultraviolet-radiation induced skin inflammation: Dissecting the role of bioactive lipids 2011, Chemistry and Physics of Lipids Citation Excerpt...