Liposomes are composed of lipid bilayer membranes that encapsulate an aqueous volume. A major challenge in the development of liposomes for drug delivery is the control of size and size distribution. In conventional methods, lipids are spontaneously assembled into heterogeneous bilayers in a bulk phase...
Morphologically, one may distinguish between small (S), large (L), giant (G), unilamellar (U), oligolamellar (O), and multilamellar (ML) vesicles (V) [1,2]. Small unilamellar vesicles (SUVs) are composed of a single lipid bilayer and are typically below 100 nm in size, whereas larg...
Liposomes are bilayer vesicles routinely used in the pharmaceutical industry as a drug delivery system for transport of chemotherapeutic drugs to the tumor area. They are composed of phospholipids that have a polar end attached to a non-polar chain that self-assemble into bilayer vesicles with the ...
liposomes, in which case multivesicular liposomes (MVL) are manufactured. MVLs can provide sustained drug release when applied in non-vascular administration due to this particular structure [25]. Liposomes are composed of sterols, surfactants and natural or synthetic phospholipids, such as egg yolk, ...
liposomes, in which case multivesicular liposomes (MVL) are manufactured. MVLs can provide sustained drug release when applied in non-vascular administration due to this particular structure [25]. Liposomes are composed of sterols, surfactants and natural or synthetic phospholipids, such as egg yolk,...
Anionic lipoplexes are composed of physiologically safe components including anionic lipids, cations, and plasmid DNA [66]. Commonly used lipids in this category are phospholipids that can be found naturally in cellular membranes such as phosphatidic acid, phosphatidylglycerol, and phosphatidylserine (...
an artificial vesicle composed of a phospholipid outer layer and an inner core of a drug or other matter to be transported into a cell. [1905–10] lip`o•so′mal,adj. Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random...
which are composed of two monolayer layer sheets of lipid molecules with their nonpolar (hydrophobic) surfaces facing each other and their polar (hydrophilic) surfaces facing the aqueous medium. The membranes enclose a portion of the aqueous phase much like the cell membrane which encloses the cell...
Liposomes are composed of a variety of lipids, both amphipathic and nonamphipathic, obtained from a variety of sources, both natural and synthetic. Suitable liposomal lipids include, without limitation, phospholipids such as phosphatidylcholines (“PC's”), phosphatidylethanolamines (“PE's”), phosp...
Described herein are ultra-deformable liposomes comprising a first lipid and second lipid. The first lipid comprises a first hydrophilic head linked to a first aliphatic tail, and t