This study evaluates the diagnostic value of serum concentrations of lipopolysaccharide-binding protein (LBP), an acute-phase protein, in children with febrile UTI and compares it to those of the total white blood cell count (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP),...
Lipopolysaccharide binding protein(LBP) is one of the key members of the innate immune response against bacteria.LBPhas been identified as a 50kDapolypeptidewhich, after post-translational processing, is released as a 60–65kDaglycoproteinin theblood stream[62–64]. Based onprimary structures...
Amniotic fluid was cultured and assayed for cytokines, and the chorioamnion and decidua were cultured and examined histologically.Lipopolysaccharide binding protein and soluble CD14 were present in all amniotic fluids and fetal cord blood. An elevated level of lipopolysaccharide binding protein (270 ng/...
another type of protein fibre is represented by the fibrin produced during blood clotting. Under normal conditions, the fibres forming the clot have an appearance in a scanning electron microscope like cooked spaghetti, and the fibres have diameters of the order...
To investigate postnatal lipopolysaccharide-binding protein (LBP) kinetics in term neonates and to test its diagnostic accuracy for early-onset bacterial infection (EOBI). A total of 99 neonates with clinical and serological signs of EOBI comprised the s
But LPS molecules may be also found in blood associated with plasma proteins such as LBP (LPS binding protein), soluble CD14 or incorporated in lipoproteins through binding to apolipoproteins (Apo). Specifically, the role of LBP has been mostly related to beneficial effects because it promotes ...
Besides lipid-binding protein (LBP), lipopolysaccharide-binding proteins are carriers for LPS in the blood. They can transfer LPS either to the macrophages or to the serum carrier lipoproteins (HDL and LDL). The transfer of LPS to macrophages initiates signal transduction to induce proinflammatory ...
B, Nox1, Nox2, and Nox4 protein expression was quantified in cell lysates by immunoblotting after silencing with the respective siRNA. C, superoxide formation was quantified in HPMECs 15 min after LPS treatment under various test conditions using a lucigenin-derived chemiluminescence assay. *, ...
LPS-binding protein is an acute-phase protein pro- duced mainly by hepatocytes, which binds with high affinity to LPS in blood plasma. Elevated LPS-binding protein levels may reflect increased maternal LPS levels. Further investigation is needed to determine the mechanism of LPS translocation and ...
In vertebrates and arthropods, blood clotting involves the establishment of a plug of aggregated thrombocytes (the cellular clot) and an extracellular fibrillar clot formed by the polymerization of the structural protein of the clot, which is fibrin in mammals, plasma lipoprotein in crustaceans, an...