Describes the redundant pathways for ligation of lipoyl groups to apoprotein by the lplA and lipB genes in lipoic acid metabolism in Escherichia coli. Lipoate utilization by fadD and fadL mutants; Detection of the lipB dependent octanoylation-lopoylation pathway; Coupling of lipoate uptake; Incor...
Structures, enzymes, and reaction mechanisms of lipoic acid metabolism. A, de novo lipoic acid synthesis and salvage pathways in E. coli. B, lipoic acid metabolic pathway in S. cerevisiae and Homo sapiens. C, orthologous enzymes associated with lipoic acid metabolism in each organism. The ...
Alpha-lipoic acid attenuates insulin resistance and improves glucose metabolism in high fat diet-fed mice 来自 Semantic Scholar 喜欢 0 阅读量: 255 作者:Y Yi,LI Wang,L Yang,LI Yan,G Ling,Jia-jun ZHAO 摘要: To investigate whether alpha-lipoic acid (ALA) could attenuate the insulin resistance...
Lipoic acid ((R)-5-(1,2-dithiolan-3-yl) pentanoic acid) is a sulfur-containing cofactor covalently attached to and essential for the function of several key enzymatic complexes of central metabolism. These include the pyruvate dehydrogenase (PDH),2 2-oxoglutarate dehydrogenase (OGDH), branched-...
Lipoic acid treatment in mice on HFD prevented several HFD-induced metabolic changes and preserved synaptic plasticity. The metabolic and physiological changes in HFD-fed mice, including insulin resistance, brain glucose uptake and metabolism, and synaptic function, could be preserved by the insulin-...
The Effect of α-Lipoic Acid on Mitochondrial Respiratory Rate and Energy Metabolism in Hepatoma Cells in Response to Hypoxia Stressα-硫辛酸对缺氧应激肝癌细胞线粒体呼吸率和产能代谢的影响 来自 OALib 喜欢 0 阅读量: 62 作者:HUANG Yongchao,SHI Dongyun,LIU Shanlin,LIU Zhixin,YU Peizhong,SHEN ...
Compares the individual effects of in vivo administration of R-(+) and S-(-) enantiomers of antioxidant alpha-lipoic acid (ALA) on in vitro insulin-stimulated glucose metabolism in skeletal muscle from obese Zucker rats. Acute in vivo administration of ALA stereoisomers; Chronic in vivo administ...
The Antioxidant ?-Lipoic Acid Enhances Insulin-Stimulated Glucose Metabolism in Insulin-Resistant Rat Skeletal Muscle Alpha-lipoic acid has been found to enhance glucose uptake into skeletal muscle in animal models. Studies have also found that the co-ingestion of carbohyd... S Jacob,RS Streeper,DL...
摘要: The invention relates to the use of the combination of n-lipoic acid and effectors of the glutathione metabolism for the treatment of disturbances of the cellular thiol status and accompanying disorders in kidney replacement therapy.收藏 引用 批量引用 报错 分享 ...