The disulfoxide of 2,4-bismethylmercapto-butanoic acid, the most polar metabolite identified, was the major metabolite in dogs. Furthermore, new data are presented that suggest conjugation with glycine occurred as a separate metabolic pathway in competition with 尾-oxidation, predominantly in mice....
Alpha-lipoic acid (α-LA), a well-known antioxidant, was proved to active ALDH2 in nitrate tolerance and diabetic animal model. However, the therapeutic advantage of α-LA for heart failure and related signaling pathway have not been explored. This study was designed to examine the role of ...
1The nucleotide sequence data of the Arabidopsis thaliana LIP1p cDNA for a lipoic acid synthase located in plastids wa doi:10.1016/S0014-5793(02)02589-9LIPOIC acidARABIDOPSIS thalianaIn eukaryotes, the biosynthetic pathway for lipoic acid is present in mitochondria. However,...
To understand the function of OS in health and disease, to examine the contributions of OS to MS pathophysiology, and to review current evidence for the effects of selected antioxidant therapies in people with MS (PwMS) with a focus on lipoic acid (LA). Recent findings Studies of antioxidant...
Alpha-lipoic acid(LA) is a powerful antioxidant.LA has two enantiomers,R(+)-LA(R-LA) and S(-)-LA(S-LA).R-LA is naturally occurring form and an essential cofactor in energy metabolism.R-LA administration has been reported to affect glucose metabolism in rat heptatoma cells.Recent study...
Activation of Phosphatidylinositol 3-kinase(PI3K)/protein kinase B (Akt) signaling pathway has been shown to improve cardiac performance during sepsis/septic shock. We have reported previously that α-lipoic acid (LA) activates PI3K/Akt pathway in neuronal cells. It is possible, therefore, that ...
1.Protective effects of alpha-lipoic acid on ischemia reperfusion injury of guinea pig cochlea;α-硫辛酸对豚鼠缺血-再灌注耳蜗损伤的防治作用 2.Objective To observe the effect of alpha-lipoic acid(LA)on the levels of NF-КB signal pathway in pancreatic tissue with acute pancreatitis(AP)and to ...
The first lipoate biosynthetic pathway determined was that of Escherichia coli, which utilizes two enzymes to form the active lipoylated protein from a fatty acid biosynthetic intermediate. Recently, a more complex pathway requiring four proteins was discovered in Bacillus subtilis, which is probably ...
Lipoic acid(LA) (Fig. 8.1) is a naturally occurring fatty acid found in yeast, spinach, broccoli, potatoes, and organ meat such as liver and kidney (Maczurek et al., 2008). Chemically, it is anorganosulfur compoundobtained fromcaprylic acid(octanoic acid).LAis a low–molecular weight compo...
Our previous study showed α-lipoic acid (LA) downregulated cell surface β1-integrin expression of v-H-ras-transformed derivative of rat fibroblast with amelioration of their malignant phenotype. Here, we evaluated the ameliorating effect of LA on the malignant characters in H-ras-transformed bladd...