Lipids and lipid-like molecules in cellular proliferation and differentiation: Potential in cancer chemoprevention and treatmentLIPID CHEMISTRY AND FUNCTIONPROLIFERATIONDIFFERENTIATIONCHEMOPREVENTIONCANCER TREATMENTLipids are integral cellular components of living organisms and play critical roles in regulating normal ...
Lipids are hydrophobic or amphiphilic small molecules that include sterols, waxes, fatty acids and phospholipids, and are insoluble in water and soluble in organic solvent. Biological lipids are generated from ketoacyl and isoprene (CH2=C(CH3)CH=CH2) groups and include glycerolipids, sphingolipids...
Na+ /H+ exchangers regulate intracellular pH, sodium levels, and cell volume. Cryo-EM structures reveal lipid coordination at the dimer interfaces of NhaA with cardiolipin and endosomal NHE9 with PI(3,5)P2. These findings demonstrate how specific lipids can regulate ion-exchange activity by stab...
The term lipid is applied to a multitude of substances of differing chemical structure and biological function whose only common feature is that they are insoluble in water but readily soluble in organic solvents such as chloroform, benzene, diethyl ether or hot ethanol. A large proportion of the...
Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to th...
Common lipid types include fats, steroids and phospholipids. Fats store energy and cushion organs, protecting them from damage, and are composed of fatty acids and glycerol, a sweet-tasting alcohol. Steroids contain four ring-shaped hydrocarbon molecules and include the dietary fat cholesterol as wel...
Food lipids are susceptible to two forms of deterioration: lipid oxidation leading to oxidative rancidity and hydrolysis of lipids by lipases (lipolysis), leading to hydrolytic rancidity. Lipid oxidation involves a very complex set of chemical reactions that have been well characterized; the literature...
Both stearic acid (a fatty acid) and phosphatidylcholine (a phospholipid) are composed of chemical groups that form polar “heads” and nonpolar “tails.” The polar heads are hydrophilic, or soluble in water, whereas the nonpolar tails are hydrophobic, or insoluble in water. Lipid molecules of...
Lipidsare integral molecules in the body’s structure, and they are important substrates for energy metabolism. Abnormalities in plasmalipidlevels (dyslipidemia), particularly cholesterol, have been associated with increased risk of cardiovascular disease. An individual’s plasmalipid profileis influenced by...
Lipids are essential building blocks synthesized by complex molecular pathways and deposited as lipid droplets (LDs) in cells. LDs are evolutionary conserved organelles found in almost all organisms, from bacteria to mammals. They are composed of a hydro