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Specifically, after screening for suitable ionizable cationic lipids and by optimizing the concentration of the synthetic lipid DMG-PEG 2000, we show that the encapsulation, via microfluidic mixing, of adenine base editor and prime editor RNPs within LNPs using the ionizable lipid SM102 can result...
8. Aragón A*, Wang Q*,Zou Y*, Morgani SM, Ruiz L, Kaczmarska Z, Su J, Torner C, Tian L, Hu J, Shu W, Agrawal S, Márquez JA, Hadjantonakis A-K, Macias MJ, and Massagué J.Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer directed TGF-β signaling...
In last decades, several colloidal carrier systems such as emulsions, liposomes and polymeric micro, and nanoparticles have been developed [42,43,44]. Among carrier systems, SLNs as an alternative carrier system to traditional colloidal carriers, are attracting major attention for various therapeutic ...
1, 5A). Because DAG acts as an inhibitor of SMS in vitro (86), the accumulation of DAG at the site of SM synthesis is somehow prevented to continue the synthesis of SM. Whereas de novo synthesis of PC largely occurs in the ER by the catalytic reaction of CEPT, CPT might contribute ...
Zhang ZY, Fan SM, Kang XQ, et al. Study on the corrlation between blood pressure variability and target organ damage of hypertensive Tibetan patients in Qinghai Yushu area. J High Alt Med. 2015;25(2):10–3. CAS Google Scholar Chen C, Liu H, Wu XH. Research progress on the mechanis...
positive polarity: 184.0739 (C5H15NO4P+) – SM; 180.0634 (NL C6H12O6) – HexCer; the characteristic product ions of the sphingoid bases for Cer, HexCer and sulfotides: 250.2534 (C17H32N+- d17:1), 264.2691 (C18H34N+- d18:1), 262.2534 (C18H32N+- d18:2), 292.3004 (C20H38N+-...
Specifically, after screening for suitable ionizable cationic lipids and by optimizing the concentration of the synthetic lipid DMG-PEG 2000, we show that the encapsulation, via microfluidic mixing, of adenine base editor and prime editor RNPs within LNPs using the ionizable lipid SM102 can result...
Mora S, Glynn RJ, Boekholdt SM, Nordestgaard BG, Kastelein JJP, Ridker PM. On-treatment non–high-density lipoprotein cholesterol, apolipoprotein B, triglycerides, and lipid ratios in relation to residual vascular risk after treatment with potent statin therapy: JUPITER (...
NLDSM: NLSD with cardiac myopathy; PAP: phosphatidic acid phosphatase; PC: Phosphatidylcholine; PDCD4: Programmed cell death 4; PE: Phosphatidylethanolamine; PI: Phosphatidylinositol; PI3K: Phosphatidylinositol 3-kinase; PKA: Protein kinase A; PLIN: Perilipin; PNPLA2: Patatin-like phospholipase domain...