The lipid-aldehyde, 4-HNE, represents one of the primary by-products of lipid peroxidation cascades and is a major contributor to pathologies generated under conditions of OS63,64. To investigate the possibility of 4-HNE as a causative intermediate of the age-related decline in oocyte quality, ...
Because the toxicity of lipid peroxidation appears to be in part due to aldehydic end products, we examined, in rat erythrocytes, the metabolism of 4-hydroxy-trans-2-nonenal (HNE), one of the most abundant and toxic lipid-derived aldehydes. Packed erythrocytes, 0.1 ml, completely metabolized ...
Protein-HNE adducts accumulate in tissues under oxidative stress; however, the mechanisms by which lipid peroxidation-derived aldehydes incite tissue injury remain unclear. We tested the hypothesis that electrophilic aldehydes trigger the unfolded protein response. Exposure of rat aortic smooth muscle cells...
Lipid Peroxidation Product, 4-HNE (4-Hydroxynonenal) Modulates hERG Channels 喜欢 0 阅读量: 20 作者: Seong Woo Choi,HyangAe Lee,YinHua Zhang,Sung Joon Kim 展开 摘要: 4-Hydroxynonenal (4-HNE) is considered as a harmful signaling molecule. The accumulation of 4-HNE is implicated under ...
A lipid peroxidation kit (Abcam, ab118970), which uses a colorimetric reaction of MDA with thiobarbituric acid, was used to quantify the MDA levels in whole-worm lysates. Worms were treated with control (empty vector) and ash-2 RNAi until middle age (adult day 5). Each condition consisted...
Lipid Peroxidation Assay Kit 英文名称: Lipid Peroxidation Assay Kit 总访问: 702 国产/进口: 进口 半年访问: 46 产地/品牌: oxford 产品类别: 免疫学/诊断检测试剂 规格: FR12 最后更新: 2024-8-13 货号: CAS 号: 参考报价: 询价 立即询价 电话咨询 ...
Lipid peroxidation is one consequence, at the cellular level, of such stresses and yields cytotoxic lipid aldehydes, including 4-hydroxy-2-nonenal (HNE), that react with specific sites in proteins, leading to diverse changes in protein function and/or stability. We have assessed the sensitivity ...
There are limited validated tools to study intra-hepatic lipid peroxidation, especially for small specimen. We developed a semi-quantitative, fully automated immunohistochemistry assay for the detection of 4-hydroxynoneal (4-HNE) protein adducts, a marker of lipid peroxidation, for adaptation to ...
4-Hydroxy-2-nonenal (HNE), a cytotoxic product of lipid peroxidation, inhibits O 2 consumption by potato tuber mitochondria. 2-Oxoglutarate dehydrogenase (... AH Millar,CJ Leaver - 《Febs Letters》 被引量: 307发表: 2000年 Mitogenic Responses of Vascular Smooth Muscle Cells to Lipid Peroxidatio...
Quantificationoflipidperoxidationisessentialtoassessoxidativestressinpathophysiologicalprocesses.LipidperoxidationformsMalondialdehyde(MDA)and4-hydroxynonenal(4-HNE),asnaturalbi-products.Measuringtheendproductsoflipidperoxidationisoneofthemostwidelyacceptedassaysforoxidativedamage.Abcam’sLipidPeroxidationAssayKitprovidesa...