A panel of 20 proteins different profile Lebrecht et al. (2009b) more than 20 proteins Increase/decrease Böhm et al. (2012) Breast, prostate, lung and colon Lacryglobin Increase Evans et al. (2001) Age-related macular degeneration Shootin-1, histatin-3, fidgetin-like protein 1, SRC ...
$ and # indicate data points corresponding to ERG response curves presented in panel j.The mice received 4.5 µg ABE RNP per eye. At least 6 eyes, mean ± s.d.; Kruskal–Wallis test with Dunn’s multiple comparisons test; ***P < 0.001. l,m, Quantification of genomic ...
Quantification of a large panel of metabolites or lipids simultaneously can be performed by measuring the mass-to- charge ratio of positively or negatively ionized molecules. Parent ions could then be fragmented to produce daughter ions that reinforce the identification process. This method has the ...
LNPs encapsulating mFluc were nebulized, collected, and administered to mice through oropharyngeal aspiration. Briefly, the mouse was anesthetized and then placed on a vertical operating table. To inhibit the swallowing reflex, the tongue was gently pulled up. The nebulized...
In the present study we did not directly measure the penetrability of the serotonin derivatives into the carotid body (CB), a sensory organ which generates the hypoxic chemoreflex. The CB is not equipped with a barrier of the BBB type and is a target tissue for N-oleoyl-dopamine [31]; ...
(green dots) cavities in GlyR–Apo (top) and GlyR–Gly (bottom) predicted using F pocket algorithm61. The cavities predicted on the surface were removed for clarity. The right and left panels are side and top views, respectively. The residues shown in sticks on the left panel are ...
Fatty acids were likely the first metabolites that were routinely reported as a panel of metabolites because of the early development of gas chromatography [27]. PUFA desaturation was presumed to be mediated by three desaturation enzymes known as the 6, 5, and 4 desaturases.However, because of...
Nociceptors and immune cells, therefore, have evolved to communicate with each other to control inflammatory and host responses against pathogens in a complementary, and yet distinct, way. That neuroimmune communication (or axon-axon immune reflex) is initiated after the release of neuropeptides [such...
Immunization with TT-MorHap either alone (H vaccine) or TT-MorHap together with palm-CV2 (H2 vaccine) caused significant reduction of heroin-associated hyper-locomotion (in Fig. 6a middle and right bottom panels are compared to the control left bottom panel). Inhibition of hyper-locomotion by...
Their activation results in local depolarisations and the generation of action potentials that are transmitted to the central nervous system, leading to reflex or conscious homeostatic responses (reviewed by [40]). Some TRP channels, TRPV1, TRPV2, TRPV3, TRPV4 and TRPM3, are gated by warm ...