allergycatalasedrugsCuZn superoxide dismutaseglutathione peroxidasehuman blood cellslipid peroxidationMn superoxide dismutaseprotein oxidative damagereactive oxygen speciesReactive oxygen species lead to lipid peroxidation and specific oxidation of some specific enzymes, proteins and other macromolecules, thus ...
Reactive oxygen species (ROS) including superoxide, hydrogen peroxide, and hydroxyl radicals, and their reactive products were classically described as harmful products of aerobic metabolism which could be capable of causing DNA mutations, lipid peroxidation (LPO) and protein oxidation [1]. Among ROS,...
•Oxidation of polyunsaturated fatty acids can yield an array of eicosanoids.•These lipid mediators play key pathophysiological roles in humans.•Ma... G Astarita,AC Kendall,EA Dennis,... - 《Biochim Biophys Acta》 被引量: 47发表: 2015年 Omega-3 Polyunsaturated Fatty Acids Suppress the ...
Increased fatty acid oxidation, lipid production, lipid absorption, and lipid storage are found in cancer cells [1]. Lipids contribute to tumor cell growth, invasion, metastasis, radiation and chemotherapy resistance. Fats encourage tumor cells to preserve their stemness by activating the Wnt and ...
As this mechanism, it was thought that atopic dermatitis caused the suppression of fatty acid β-oxidation. These results suggest that atopic dermatitis causes lipid accumulation in the liver. 展开 关键词: allergy DNA microarray lipid metabolism liver NC/Nga ...
Mitochondrial dysfunction [beta-oxidation Ac CoA malonyl fatty acid] Insulin resistance/sensitive [more important than BMI], known as a driver to cancer development Membrane instability Inflammation in the gut [mucin layer and tight junctions] Epigenetics/Methylation Autophagy [AMPKbeta1 improvement in ...
Free MCFAs do not need to be transported by carnitine palmitoyl transferase to the mitochondria in order to undergo beta-oxidation; because of this they are preferentially oxidized over long chain fatty acids for energy52. Oxidation of free MCFAs may also contribute to a ketotic state, because...
Although the effects of resistant starch (RS) on postprandial glycemia and insulinemia have been extensively studied, little is known about the impact of RS on fat metabolism. This study examines the relationship between the RS content of a meal and postprandial/post-absorbative fat oxidation. Res...
(AMPK), which is a master regulator of metabolism. When cellular ATP levels decrease, AMPK is activated and suppresses anabolic activities, including lipid and protein synthesis, and enhances catabolic activities, including lipid oxidation and glucose metabolism to restore energy homeostasis145. Webb ...
This suggests that muscle fat turnover (lipolysis/oxidation) leading to accumulation of bioactive lipid metabolites such as DAG and others is critical in FA-induced IR (Samuel and Shulman, 2016; Stinkens et al., 2015), and to skeletal muscle inflammation (see below). An immanent part of mus...