In this Review, we summarize and discuss the complex landscape of processes involved in lipid metabolism, remodelling and intercellular transfer in the CNS. Highlighted are key pathways, including those mediating lipid (and lipid droplet) biogenesis and breakdown, lipid oxidation and phospholipid ...
Innate immune detection of lipid oxidation as a threat assessment strategy Article 21 September 2021 References Zadoorian A, Du X, Yang H. Lipid droplet biogenesis and functions in health and disease. Nat Rev Endocrinol. 2023;19:443–59. Article CAS PubMed Google Scholar Olzmann JA, Carv...
NO(2)), respectively, reactive intermediates capable of initiating oxidation of lipids in plasma. Neither the ability of MPO to initiate lipid peroxidation in vivo nor its role in generating bioactive eicosanoids during inflammation has been reported. Using a model of inflammation (peri...
Decades of research have been done on liposomes, solid lipid nanoparticles (SLN), and nanostructured lipid carriers (NLC) as a part of lipid-based nanoparticles used as a drug delivery vehicle. Liposomes showed advantages like low toxicity, biocompatibility (as phosopholipid either from natural or ...
their gene expression, whereas a severe defect in classical BAT development prevents this increase. 12,13-DiHOME increases FA uptake in BAT by promoting the translocation of FA transporters118. This reduces circulating TG levels and enhances cold adaptation by augmenting lipid oxidation, especially the...
oxidation, lipid production, lipid absorption, and lipid storage are found in cancer cells [1]. Lipids contribute to tumor cell growth, invasion, metastasis, radiation and chemotherapy resistance. Fats encourage tumor cells to preserve their stemness by activating the Wnt and Notch signaling pathways...
Just as LDs can grow, they can also decrease in size or be completely resorbed and this regression can occur through a number of mechanisms. LDs are the primary source of fatty acids for β-oxidation in mitochondria. Thus mitochondrial energy requirements can drive LD regression mediated mainly ...
Mitochondrial dysfunction [beta-oxidation Ac CoA malonyl fatty acid] Insulin resistance/sensitive [more important than BMI], known as a driver to cancer development Membrane instability Inflammation in the gut [mucin layer and tight junctions] Epigenetics/Methylation Autophagy [AMPKbeta1 improvement in ...
The main beta-oxidation pathway degrades both saturated and unsaturated fatty acids while the auxiliary pathway performs additional steps required for the degradation of unsaturated fatty acids. The pathways of mitochondrial and peroxisomal beta-oxidation use similar enzymes, but have different substrate ...
The oxidation is carried out using a peroxide such as an aqueous hydrogen peroxide, m-chloroperbenzoic acid, peracetic acid, tert-butyl hydroperoxide, or the like in a solvent such as an alcohol (e.g., methanol, ethanol) or a chlorinated hydrocarbon (e.g., dichloromethane, chloroform) at ...