Fig. 2: Glycogen metabolism is altered under hypoxia via PQM-1’s regulation of sodh-1. a One-class SAM analysis of gene expression changes in pqm-1(ok485) mutants +CoCl2 versus wild type (WT) +CoCl2 identified 1650 upregulated and 629 downregulated genes (Supplementary Data 2). b, c...
Understanding the interface between nanomaterials and lipoproteins is crucial for gaining insights into their impact on lipoprotein structure and lipid metabolism. Here, we use graphene oxide (GOs) nanosheets as a controlled carbon nanomaterial model to study how surface properties influence lipoprotein coro...
Mutant Gene Expression, Myocardial adenine nucleotide metabolism, Myocardial Ischemia, Myocardial Metabolism, Myocardial metabolism, Myocardial ischemia, myocardial perfusion, Myocardial adenine nucleotide metabolism, Na-K transport, Na-K-ATPase, Nanotechnology for Drug Delivery, Neurodegenerative Diseases, Neurohu...
Although lipid droplet accumulation has been observed in hypoxic cells within several tumor types [19, 20], differential lipid metabolism between heterogeneous GBM cell types and microen- vironments has remained unexplored. In this study, we analyzed spatial alterations in gene expression and lipid ...
We performed gene ontology analysis using the web-based application GOTM (http://bioinfo.vanderbilt.edu/gotm/) on the 279 differentially expressed genes. Melanin biosynthesis, lipid metabolism, and prostaglandin metabolism were identified as the most affected biological processes (Table 2). All four ...
To characterize more promising candidate genes, the correlations of gene expression profiles with blood lipid traits were evaluated using porcine liver samples as liver is a metabolically active organ and is critical to blood lipid metabolism. We detected functional candidate genes for these traits by...
Target Engagement and Lipid Metabolism Effects of NUCB1 Ligands, Related to Figure 7 (A) Concentration-dependent competition of AEA-DA (5 μM) probe labeling of NUCB1 and select off-targets (ABCB1B, TMEM97, CERS2, NUCB2) by MJN228 in Neuro2a cells. Data are normalized to the maximal ...
FGF15 signaling pathway followed by down-regulatingCyp7a1,Cyp8b1,Cyp27a1andCyp7b1gene expression. Furthermore, XKY regulates amino acid metabolism including arginine biosynthesis, alanine, aspartate and glutamate metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, and tryptophan metabolism ...
Linear fitting of RNA-seq and qRT-PCR gene expression data. The DEGs related to fat metabolism were selected for qRT-PCR analysis. The 14 selected genes showed consistent results between the RNA-seq and qRT-PCR analyses, with a correlation coefficient (R2) = 0.97302. Full size image Fig...
the transcriptional profile of the TREM2hiLAM cluster is consistent with the expression ofNR1H3—the gene encoding the transcription factor LXRa and a signature of lipid uptake, lysosomal metabolism, antioxidative functions, matrix remodeling, cholesterol metabolism and efflux, with a notable lack of...