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Here, we provide an update on the current understanding of the biogenesis and functions of lipid droplets in health and disease, highlighting a key role for lipid droplet biogenesis in alleviating cellular stresses. We also discuss therapeutic strategies of targeting lipid droplet biogenesis, growth ...
Lipid metabolismrefers to the process of digestion, absorption, synthesis, and decomposition of fats in living organisms by variousenzymes. The metabolites includeadipokines, fatty acids, and cholesterol substances. Adipokines regulate the endocrine metabolic functions of adipocytes, which secrete dozens of...
Lipidshave multiple essential functions in cells[186]including support and integrity via membranes, as signaling molecules and messengers across diversesignaling pathways, and as an energy source in the unavailability of glucose via β-oxidation of fatty acids. Because of these central roles, cells hav...
Background: Lysophosphatidic acid receptors (LPARs) are important to normal cellular functions and implicated in the pathogenesis and survival of various cancers recently. Previous studies were mostly focused on one LPAR using experiment... A Bingham,J Mao,C Wang,... - 《Cancer Research》 被引量...
Tumor cells and cells in TME interact with each other and form a reciprocal entity [6]. On one hand, tumor cells can actively modify the TME by secreting signaling molecules and metabolites, which affect the functions of cancer-associated fibroblasts (CAFs) and immune cells in TME [6]. On...
Effects of dietary sodium on performance, flight and compensation strategies in the cotton bollworm, Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) p pBackground/p pSodium is critical for many physiological functions in insects. Herbivorous insects should expend considerable energy to compensate ...
Lipid droplets are cytosolic organelles that, among other functions, serve as a storage medium for the fatty acids, protecting the cell from oxidative damage and providing an energy source to maintain proliferation in unfavorable microenvironments. Lipid droplet formation particularly occurs under ...
Renishaw Wire 4.1 was used to perform basic pre-processing steps using the inbuilt functions in the software. Cosmic rays were removed followed by baseline subtraction. Baseline was subtracted using the in-built baseline subtraction intelligent fitting function (with an 11th order polynomial fitting and...
R. et al. Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology. Mol. Biol. Cell 26, 726–739 (2015). Article PubMed PubMed Central CAS Google Scholar Wang, H. et al. Seipin is required for converting nascent to mature lipid droplets....