A distinctive feature of cancer cells is the large number of cellular LDs. Cancer cells are metabolically active compared to normal cells, with greatly enhanced lipid uptake and synthesis. Cancer cells have elevated expression levels of the fatty acid transport protein such as FABPs, which contribut...
Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review the current understanding of the mechanisms of lipid droplet biogenesis and turnover, the transfer of lipids and metabo...
Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain uncontrolled proliferation and survive in unfavorable environments that lack oxygen and nutrients, tumor cells undergo metabolic transformations to exploit various ways
Cytoplasmic lipid droplets are important organelles in nearly every eukaryotic and some prokaryotic cells. Storing and providing energy is their main function, but they do not work in isolation. They respond to stimuli initiated either on the cell surface or in the cytoplasm as conditions change. ...
Lipids are essential building blocks synthesized by complex molecular pathways and deposited as lipid droplets (LDs) in cells. LDs are evolutionary conserved organelles found in almost all organisms, from bacteria to mammals. They are composed of a hydrophobic neutral lipid core surrounding by a phosp...
Although all cells seem to be able to generate lipid droplets, their biogenesis, regulatory mechanisms and interactions with other organelles remain largely elusive. In this article, we outline some of the recent developments in lipid droplet cell biology. We show the mobile and dynamic nature of ...
Aifm2 increases overall mitochondrial activity in BAT cells and transfers electrons to the electron transport chain, providing fuel for thermogenesis and promoting uncoupled respiration and thermogenesis [77]. However, there are many questions regarding the role of Aifm2 in thermogenesis that require ...
Local environment of the lipid droplets inside the breast cancer cells, MCF7 and in non-malignant breast cells, MCF10A is monitored using time-resolved confocal microscopy. For this study, a coumarin-based dye C153 has been used. The local polarity and the solvation dynamics indicate that a ...
In addition, we propose that the larger LDAP/SRPP protein family plays important roles in the compartmentalization of lipophilic compounds, including triacylglycerols and polyisoprenoids, into lipid droplets within plant cells. Potential roles in lipid droplet biogenesis and function of these proteins ...
LIPID DROPLETS SUPPORT THE CELL GROWTH AND PROLIFERATION AND ALLEVIATE THE STARVATION INDUCED CELL DEATH IN THE LUNG CANCER CELLS 来自 Semantic Scholar 喜欢 0 阅读量: 8 作者:MS Hung,YC Lin,SL Huang,YY Jiang,TM Yang,YH Tsai,J Lung